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Sez6l2 seizure related 6 homolog like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308988, updated on 9-Dec-2024

Summary

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Official Symbol
Sez6l2provided by RGD
Official Full Name
seizure related 6 homolog like 2provided by RGD
Primary source
RGD:1565281
See related
EnsemblRapid:ENSRNOG00000027098 AllianceGenome:RGD:1565281
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1565281
Summary
Predicted to be involved in regulation of protein kinase C signaling and synapse maturation. Predicted to act upstream of or within adult locomotory behavior and cerebellar Purkinje cell layer development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and neuronal cell body. Orthologous to human SEZ6L2 (seizure related 6 homolog like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Brain (RPKM 150.5), Adrenal (RPKM 14.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Sez6l2 in Genome Data Viewer
Location:
1q37
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190987647..191007990)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181557109..181577456)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198383201..198403544)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 13 Neighboring gene aspartate beta-hydroxylase domain containing 1 Neighboring gene CDIP transferase, opposite strand Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. Miyazaki T, et al. FEBS Lett, 2006 Jul 24. PMID 16814779
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase C signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synapse maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
seizure 6-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107550.2 → NP_001101020.1  seizure 6-like protein 2 precursor

    See identical proteins and their annotated locations for NP_001101020.1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I9J3, D4A6P1
    Related
    ENSRNOP00000035589.3, ENSRNOT00000037405.5
    Conserved Domains (4) summary
    cd00033
    Location:290 → 345
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:665 → 828
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:527 → 617
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:466 → 523
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190987647..191007990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006230264.2 → XP_006230326.1  seizure 6-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQG6
    Related
    ENSRNOP00000080735.1, ENSRNOT00000118351.2
    Conserved Domains (4) summary
    cd00033
    Location:290 → 345
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:665 → 828
    PHA02927; secreted complement-binding protein; Provisional
    cd00041
    Location:527 → 617
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00084
    Location:466 → 523
    Sushi; Sushi repeat (SCR repeat)
Nucleotide Protein Strain
Heading Accession and Version

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