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Fbxl19 F-box and leucine-rich repeat protein 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308999, updated on 27-Nov-2024

Summary

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Symbol
Fbxl19provided by RGD
Full Name
F-box and leucine-rich repeat protein 19provided by RGD
Primary source
RGD:1310989
See related
EnsemblRapid:ENSRNOG00000018986 AllianceGenome:RGD:1310989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ubiquitin-like ligase-substrate adaptor activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL19 (F-box and leucine rich repeat protein 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 68.4), Testes (RPKM 60.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl19 in Genome Data Viewer
Location:
1q37
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191786981..191811314)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182356899..182380839)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199196126..199217147)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BAF chromatin remodeling complex subunit BCL7C Neighboring gene microRNA 762 Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2 Neighboring gene uncharacterized LOC134483922 Neighboring gene ORAI calcium release-activated calcium modulator 3 Neighboring gene SET domain containing 1A, histone lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Zhao J, et al. Nat Immunol, 2012 Jun 3. PMID 22660580, Free PMC Article
  2. DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants. Xu C, et al. Structure, 2018 Jan 2. PMID 29276034
  3. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415928.1 → NP_001402857.1  F-box/LRR-repeat protein 19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2KB30
    Related
    ENSRNOP00000059635.2, ENSRNOT00000065187.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191786981..191811314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078403.2 → XP_038934331.1  F-box/LRR-repeat protein 19 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KB30
    Conserved Domains (5) summary
    cd09293
    Location:446 → 645
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:466 → 489
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:67 → 128
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam02008
    Location:30 → 57
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:404 → 445
    F-box-like

  2. XM_039078404.2 → XP_038934332.1  F-box/LRR-repeat protein 19 isoform X3

    UniProtKB/TrEMBL
    A0A0G2KB30
    Conserved Domains (5) summary
    cd09293
    Location:446 → 645
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:466 → 489
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:67 → 128
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam02008
    Location:30 → 57
    zf-CXXC; CXXC zinc finger domain
    pfam12937
    Location:404 → 445
    F-box-like

  3. XM_006230278.5 → XP_006230340.1  F-box/LRR-repeat protein 19 isoform X4

    Conserved Domains (5) summary
    cd09293
    Location:438 → 637
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:95 → 122
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:458 → 481
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:132 → 193
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam12937
    Location:396 → 439
    F-box-like; F-box-like

  4. XM_006230279.5 → XP_006230341.1  F-box/LRR-repeat protein 19 isoform X5

    UniProtKB/TrEMBL
    A6I9T8, D4A2L9
    Conserved Domains (5) summary
    cd09293
    Location:395 → 594
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:95 → 122
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:415 → 438
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:132 → 193
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam12937
    Location:353 → 396
    F-box-like; F-box-like

  5. XM_006230277.5 → XP_006230339.1  F-box/LRR-repeat protein 19 isoform X2

    Conserved Domains (5) summary
    cd09293
    Location:468 → 667
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:95 → 122
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:488 → 511
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:132 → 193
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam12937
    Location:426 → 469
    F-box-like; F-box-like

  6. XM_006230276.5 → XP_006230338.1  F-box/LRR-repeat protein 19 isoform X1

    Related
    ENSRNOP00000075629.2, ENSRNOT00000090428.3
    Conserved Domains (5) summary
    cd09293
    Location:511 → 710
    AMN1; Antagonist of mitotic exit network protein 1
    pfam02008
    Location:95 → 122
    zf-CXXC; CXXC zinc finger domain
    sd00034
    Location:531 → 554
    LRR_AMN1; leucine-rich repeat [structural motif]
    cd15645
    Location:132 → 193
    PHD_FXL19; PHD finger found in F-box and leucine-rich repeat protein 19 (FBXL19)
    pfam12937
    Location:469 → 512
    F-box-like; F-box-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107552.1: Suppressed sequence

    Description
    NM_001107552.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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