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Zfp668 zinc finger protein 668 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309002, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp668provided by RGD
Official Full Name
zinc finger protein 668provided by RGD
Primary source
RGD:1308623
See related
EnsemblRapid:ENSRNOG00000016683 AllianceGenome:RGD:1308623
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf668; RGD1308623
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in DNA repair and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF668 (zinc finger protein 668). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 33.8), Brain (RPKM 25.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp668 in Genome Data Viewer
Location:
1q37
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191905112..191915436, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182474633..182484957, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199310935..199321231, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene syntaxin 1B Neighboring gene uncharacterized LOC134483916 Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 646 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Kim S, et al. Immunity, 2004 Nov. PMID 15539151
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 668

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107553.1 → NP_001101023.1  zinc finger protein 668

    See identical proteins and their annotated locations for NP_001101023.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473956
    UniProtKB/TrEMBL
    A6I9V8
    Related
    ENSRNOP00000022452.5, ENSRNOT00000022452.9
    Conserved Domains (4) summary
    COG5048
    Location:65 → 419
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:226 → 246
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:544 → 566
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:210 → 235
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    191905112..191915436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589218.2 → XP_017444707.1  zinc finger protein 668 isoform X3

    UniProtKB/TrEMBL
    D3ZPP0

  2. XM_039078439.2 → XP_038934367.1  zinc finger protein 668 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A933
    Conserved Domains (2) summary
    COG5048
    Location:76 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017589216.3 → XP_017444705.1  zinc finger protein 668 isoform X3

    UniProtKB/TrEMBL
    D3ZPP0

  4. XM_017589214.3 → XP_017444703.1  zinc finger protein 668 isoform X1

    Related
    ENSRNOP00000108674.1, ENSRNOT00000168166.1

  5. XM_039078442.2 → XP_038934370.1  zinc finger protein 668 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A933
    Related
    ENSRNOP00000089577.1, ENSRNOT00000097525.2
    Conserved Domains (2) summary
    COG5048
    Location:76 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237 → 257
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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