Adgra1 adhesion G protein-coupled receptor A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adgra1provided by RGD
Official Full Name: adhesion G protein-coupled receptor A1provided by RGD
Primary source: RGD:1308241
See related: EnsemblRapid:ENSRNOG00000054955 AllianceGenome:RGD:1308241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr123
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in glutamatergic synapse and postsynaptic density. Orthologous to human ADGRA1 (adhesion G protein-coupled receptor A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 59.0), Adrenal (RPKM 12.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (204059218..204102869)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (194629744..194673254)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (212170190..212213156)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE107869 (e-PCR)
- UniSTS:247098

RH144323 (e-PCR)
- UniSTS:233568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable G-protein coupled receptor 123; adhesion G protein-coupled receptor A1

Names: G protein-coupled receptor 123

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432263.1 → NP_001419192.1 probable G-protein coupled receptor 123

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K4I3
NM_001432264.1 → NP_001419193.1 probable G-protein coupled receptor 123

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K4I3

RNA

NR_197277.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

204059218..204102869

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101254.2 → XP_038957182.1 adhesion G protein-coupled receptor A1 isoform X1

Conserved Domains (2) summary

cd14964
Location:19 → 44

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:17 → 328

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039101255.2 → XP_038957183.1 adhesion G protein-coupled receptor A1 isoform X2

Conserved Domains (2) summary

cd14964
Location:135 → 152

7tm_GPCRs; TM helix 4 [structural motif]

cl28897
Location:135 → 325

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039101253.2 → XP_038957181.1 adhesion G protein-coupled receptor A1 isoform X1

Related

ENSRNOP00000073055.2, ENSRNOT00000085921.3

Conserved Domains (2) summary

cd14964
Location:19 → 44

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:17 → 328

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107559.1: Suppressed sequence

Description

NM_001107559.1: This RefSeq was temporarily suppressed because there is insufficient transcript data. The RefSeq cannot be derived from the draft reference genomic sequence because it contains a gap such that the correct protein cannot be represented.