H19 H19 imprinted maternally expressed transcript [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: H19provided by RGD
Official Full Name: H19 imprinted maternally expressed transcriptprovided by RGD
Primary source: RGD:2775
See related: AllianceGenome:RGD:2775
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ASM; ASM1; D11S813E
Summary: Involved in several processes, including negative regulation of cytokine production; positive regulation of cardiac muscle cell proliferation; and regulation of apoptotic process. Used to study acute myocardial infarction; dilated cardiomyopathy; middle cerebral artery infarction; and myocardial infarction. Biomarker of hepatocellular carcinoma; middle cerebral artery infarction; pre-eclampsia; and transitional cell carcinoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 33876.1) and Liver (RPKM 5195.4) See more
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Genomic context

Location:: 1q41

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (207160175..207162851, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (197730698..197733374, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (215744404..215747080, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p/TGF-betaR1/COL1A1 axis.
Title: LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p/TGF-βR1/COL1A1 axis.
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis.
Title: Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis.
Long Non-coding RNA H19 Promotes NLRP3-Mediated Pyroptosis After Subarachnoid Hemorrhage in Rats.
Title: Long Non-coding RNA H19 Promotes NLRP3-Mediated Pyroptosis After Subarachnoid Hemorrhage in Rats.
The interplay between H19 and HIF-1alpha in mitochondrial dysfunction in myocardial infarction.
Title: The interplay between H19 and HIF-1α in mitochondrial dysfunction in myocardial infarction.
[Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.
Title: Upregulated LncRNA H19 Sponges MiR-106a-5p and Contributes to Aldosterone-Induced Vascular Calcification via Activating the Runx2-Dependent Pathway.
The Long Noncoding RNA H19 Promotes Fibrotic Processes in Lens Epithelial Cells.
Title: The Long Noncoding RNA H19 Promotes Fibrotic Processes in Lens Epithelial Cells.
LncRNA H19 Regulates P-glycoprotein Expression Through the NF-kappaB Signaling Pathway in the Model of Status Epilepticus.
Title: LncRNA H19 Regulates P-glycoprotein Expression Through the NF-κB Signaling Pathway in the Model of Status Epilepticus.
H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis.
Title: H19 silencing decreases kainic acid-induced hippocampus neuron injury via activating the PI3K/AKT pathway via the H19/miR-206 axis.
Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic-Ischemic Encephalopathy.
Title: Mechanisms Underlying Abnormal Expression of lncRNA H19 in Neonatal Hypoxic-Ischemic Encephalopathy.

Submit: New GeneRIF Correction See all GeneRIFs (57)

General gene information

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Markers

RH128414 (e-PCR)
- UniSTS:211722

UniSTS:265491 (e-PCR)
- UniSTS:265491

H19 (e-PCR), detects polymorphism
- UniSTS:265491

UniSTS:265492 (e-PCR)
- UniSTS:265492

H19 (e-PCR), detects polymorphism
- UniSTS:265492

H19 (e-PCR), detects polymorphism
- UniSTS:516447

H19 (e-PCR), detects polymorphism
- UniSTS:532137

H19 (e-PCR), detects polymorphism
- UniSTS:143288

H19 (e-PCR), detects polymorphism
- UniSTS:143291

H19 (e-PCR), detects polymorphism
- UniSTS:143294

UniSTS:143296 (e-PCR)
- UniSTS:143296

H19 (e-PCR), detects polymorphism
- UniSTS:143296

NoName (e-PCR)
- UniSTS:532168

H19 (e-PCR), detects polymorphism
- UniSTS:532168

UniSTS:265459 (e-PCR)
- UniSTS:265459

H19 (e-PCR), detects polymorphism
- UniSTS:265459

Other Names

H19 fetal liver mRNA
H19, imprinted maternally expressed transcript (non-protein coding)

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within genomic imprinting	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesenchymal to epithelial transition	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in skeletal muscle tissue development	IEP Inferred from Expression Pattern more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.