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Mtmr10 myotubularin related protein 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309255, updated on 4-Jan-2025

Summary

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Official Symbol
Mtmr10provided by RGD
Official Full Name
myotubularin related protein 10provided by RGD
Primary source
RGD:1305958
See related
EnsemblRapid:ENSRNOG00000016090 AllianceGenome:RGD:1305958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305958
Summary
Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR10 (myotubularin related protein 10). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 185.7), Lung (RPKM 106.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtmr10 in Genome Data Viewer
Location:
1q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127271139..127322621)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117859355..117910839)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125124743..125175857)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099837 Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene FANCD2 and FANCI associated nuclease 1 Neighboring gene M-phase phosphoprotein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myotubularin-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100846.1 → NP_001094316.1  myotubularin-related protein 10

    See identical proteins and their annotated locations for NP_001094316.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6B2M4, A6JBK9, G3V810
    Related
    ENSRNOP00000096606.2, ENSRNOT00000114828.2
    Conserved Domains (3) summary
    cd13346
    Location:21 → 193
    PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam12578
    Location:574 → 701
    3-PAP; Myotubularin-associated protein
    cl21483
    Location:222 → 503
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    127271139..127322621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079931.2 → XP_038935859.1  myotubularin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B2M4
    Conserved Domains (3) summary
    cd14593
    Location:193 → 386
    PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
    pfam12578
    Location:492 → 619
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:1 → 111
    PH-like; Pleckstrin homology-like domain

  2. XM_039079929.2 → XP_038935857.1  myotubularin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B2M4
    Conserved Domains (3) summary
    cd14593
    Location:193 → 386
    PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
    pfam12578
    Location:492 → 619
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:1 → 111
    PH-like; Pleckstrin homology-like domain

  3. XM_039079926.2 → XP_038935854.1  myotubularin-related protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B2M4
    Conserved Domains (3) summary
    cd14593
    Location:193 → 386
    PTP-MTMR10; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 10
    pfam12578
    Location:492 → 619
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:1 → 111
    PH-like; Pleckstrin homology-like domain

  4. XM_063264488.1 → XP_063120558.1  myotubularin-related protein 10 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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