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Trex2 three prime repair exonuclease 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309275, updated on 4-Jan-2025

Summary

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Official Symbol
Trex2provided by RGD
Official Full Name
three prime repair exonuclease 2provided by RGD
Primary source
RGD:1562245
See related
EnsemblRapid:ENSRNOG00000056983 AllianceGenome:RGD:1562245
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562245
Summary
Predicted to enable several functions, including 3'-5'-DNA exonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA catabolic process. Predicted to be active in cytoplasm. Orthologous to human TREX2 (three prime repair exonuclease 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 13.3) and Testes (RPKM 2.3) See more
Orthologs
human mouse all
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Genomic context

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See Trex2 in Genome Data Viewer
Location:
Xq37
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156303203..156304811, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151151862..151153470, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (157374305..157375913)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene PNMA family member 6E Neighboring gene ZFP92 zinc finger protein Neighboring gene potassium two pore domain channel subfamily K member 6, pseudogene 1 Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene biglycan

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins. Mazur DJ, et al. J Biol Chem, 2001 May 18. PMID 11279105
  2. Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin. Chu Q, et al. Clin Exp Ophthalmol, 2011 Mar. PMID 20973890
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5'-DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
three prime repair exonuclease 2
NP_001101050.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107580.1 → NP_001101050.1  three prime repair exonuclease 2

    See identical proteins and their annotated locations for NP_001101050.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474099
    UniProtKB/TrEMBL
    A6KRY6, D4A3I6
    Related
    ENSRNOP00000075461.1, ENSRNOT00000081973.3
    Conserved Domains (1) summary
    cd06136
    Location:10 → 204
    TREX1_2; DEDDh 3'-5' exonuclease domain of three prime repair exonuclease (TREX)1, TREX2, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    156303203..156304811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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