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Mamdc2 MAM domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309410, updated on 27-Nov-2024

Summary

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Official Symbol
Mamdc2provided by RGD
Official Full Name
MAM domain containing 2provided by RGD
Primary source
RGD:1305129
See related
EnsemblRapid:ENSRNOG00000024620 AllianceGenome:RGD:1305129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycosaminoglycan binding activity. Predicted to be located in endoplasmic reticulum and interstitial matrix. Orthologous to human MAMDC2 (MAM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 222.8), Uterus (RPKM 145.1) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mamdc2 in Genome Data Viewer
Location:
1q51
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (230290482..230443014, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (220863959..221016493, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (241071110..241223798, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S12-like Neighboring gene structural maintenance of chromosomes 5 Neighboring gene RNA, U6 small nuclear 806 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in interstitial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAM domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100696.1 → NP_001094166.1  MAM domain-containing protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F1M9P7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    230290482..230443014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101390.2 → XP_038957318.1  MAM domain-containing protein 2 isoform X1

    Related
    ENSRNOP00000038144.7, ENSRNOT00000034216.8
    Conserved Domains (2) summary
    cd06263
    Location:509 → 664
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    pfam00629
    Location:170 → 327
    MAM; MAM domain, meprin/A5/mu

  2. XM_063281029.1 → XP_063137099.1  MAM domain-containing protein 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials