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Dmrt2 doublesex and mab-3 related transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309430, updated on 27-Nov-2024

Summary

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Official Symbol
Dmrt2provided by RGD
Official Full Name
doublesex and mab-3 related transcription factor 2provided by RGD
Primary source
RGD:1309047
See related
EnsemblRapid:ENSRNOG00000016301 AllianceGenome:RGD:1309047
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 72.1), Thymus (RPKM 55.4) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dmrt2 in Genome Data Viewer
Location:
1q51
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (232743935..232750431)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (223317543..223324131)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (243662819..243669312)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene doublesex and mab-3 related transcription factor 3 Neighboring gene transfer RNA proline (anticodon AGG) 60 Neighboring gene uncharacterized LOC108349212

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dmrt2 and Pax3 double-knockout mice show severe defects in embryonic myogenesis. Seo KW. Comp Med, 2007 Oct. PMID 17974128
  2. Left-right function of dmrt2 genes is not conserved between zebrafish and mouse. Lourenço R, et al. PLoS One, 2010 Dec 28. PMID 21203428, Free PMC Article
  3. Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA. Murphy MW, et al. BMC Mol Biol, 2007 Jul 2. PMID 17605809, Free PMC Article
  4. Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning. Seo KW, et al. Dev Biol, 2006 Feb 1. PMID 16387292
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within left/right pattern formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of myotome development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of myotome development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of somitogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107597.1 → NP_001101067.1  doublesex- and mab-3-related transcription factor 2

    See identical proteins and their annotated locations for NP_001101067.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6I0S3, D4A098
    Related
    ENSRNOP00000059880.2, ENSRNOT00000067372.3
    Conserved Domains (1) summary
    pfam00751
    Location:117 → 163
    DM; DM DNA binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    232743935..232750431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760307.3 → XP_008758529.1  doublesex- and mab-3-related transcription factor 2 isoform X3

    See identical proteins and their annotated locations for XP_008758529.1

    Conserved Domains (1) summary
    pfam00751
    Location:117 → 163
    DM; DM DNA binding domain

  2. XM_039080293.2 → XP_038936221.1  doublesex- and mab-3-related transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    D4A098

  3. XM_063264772.1 → XP_063120842.1  doublesex- and mab-3-related transcription factor 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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