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Tnks2 tankyrase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309512, updated on 27-Nov-2024

Summary

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Symbol
Tnks2provided by RGD
Full Name
tankyrase 2provided by RGD
Primary source
RGD:1305026
See related
EnsemblRapid:ENSRNOG00000052664 AllianceGenome:RGD:1305026
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity and enzyme binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnks2 in Genome Data Viewer
Location:
1q53
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243980432..244033629)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234567888..234621079)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906945.1 (98838..152861)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485232 Neighboring gene small nucleolar RNA U3 Neighboring gene uncharacterized LOC120100026 Neighboring gene fibroblast growth factor binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tankyrase 2 poly(ADP-ribose) polymerase domain-deleted mice exhibit growth defects but have normal telomere length and capping. Hsiao SJ, et al. Mol Cell Biol, 2006 Mar. PMID 16507985, Free PMC Article
  2. Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Chiang YJ, et al. Mol Cell Biol, 2006 Mar. PMID 16507984, Free PMC Article
  3. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression. Kaminker PG, et al. J Biol Chem, 2001 Sep 21. PMID 11454873
  4. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Kulak O, et al. Mol Cell Biol, 2015 Jul. PMID 25939383, Free PMC Article
  5. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. Yang M, et al. FEBS J, 2011 Apr. PMID 21251231, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomere lengthening ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in protein auto-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
involved_in protein poly-ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
tankyrase-2-like
NP_001101077.2
XP_038936561.1
XP_038936562.1
XP_063121260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107607.2 → NP_001101077.2  poly [ADP-ribose] polymerase tankyrase-2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JTB0
    Related
    ENSRNOP00000068637.2, ENSRNOT00000079808.3
    Conserved Domains (8) summary
    cd09524
    Location:871 → 936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:877 → 933
    SAM; Sterile alpha motif
    cd00204
    Location:518 → 643
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:938 → 1160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:952 → 1155
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:530 → 622
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 78
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    243980432..244033629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080634.2 → XP_038936562.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    UniProtKB/TrEMBL
    D3ZRP5
    Related
    ENSRNOP00000073499.2, ENSRNOT00000085497.3
    Conserved Domains (5) summary
    PTZ00322
    Location:27 → 113
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02876
    Location:73 → 458
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:808 → 873
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    cd01438
    Location:875 → 1097
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]

  2. XM_039080633.2 → XP_038936561.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    Related
    ENSRNOP00000098656.1, ENSRNOT00000132955.1
    Conserved Domains (5) summary
    cd09524
    Location:814 → 879
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:437 → 745
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:881 → 1103
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:471 → 499
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:364 → 415
    Ank_5; Ankyrin repeats (many copies)

  3. XM_063265190.1 → XP_063121260.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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