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Tcp11 t-complex 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309641, updated on 4-Jan-2025

Summary

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Official Symbol
Tcp11provided by RGD
Official Full Name
t-complex 11provided by RGD
Primary source
RGD:1359387
See related
EnsemblRapid:ENSRNOG00000000499 AllianceGenome:RGD:1359387
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; protein kinase A signaling; and regulation of sperm capacitation. Predicted to be located in sperm midpiece. Predicted to be active in acrosomal vesicle and sperm flagellum. Orthologous to human TCP11 (t-complex 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 1030.9) See more
Orthologs
human mouse all
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Genomic context

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See Tcp11 in Genome Data Viewer
Location:
20p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6128001..6140152, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6126267..6138408, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (7645619..7657222, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene uncharacterized LOC102552617 Neighboring gene uncharacterized LOC108349039 Neighboring gene uncharacterized LOC120098860 Neighboring gene signal peptide, CUB domain and EGF like domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway. Adeoya-Osiguwa SA, et al. Mol Reprod Dev, 1998 Dec. PMID 9820206
  2. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. Liu Y, et al. Tohoku J Exp Med, 2011 Jun. PMID 21597245
  3. TCP-11, the product of a mouse t-complex gene, plays a role in stimulation of capacitation and inhibition of the spontaneous acrosome reaction. Fraser LR, et al. Mol Reprod Dev, 1997 Nov. PMID 9322250
  4. A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation. Stanger SJ, et al. FASEB J, 2016 Aug. PMID 27105888
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95257

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in germ cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein kinase A signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sperm capacitation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
T-complex protein 11 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007695.1 → NP_001007696.1  T-complex protein 11 homolog

    See identical proteins and their annotated locations for NP_001007696.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083899
    UniProtKB/Swiss-Prot
    Q5XI00
    UniProtKB/TrEMBL
    A6JJP5
    Related
    ENSRNOP00000039755.4, ENSRNOT00000045044.6
    Conserved Domains (1) summary
    pfam05794
    Location:143 → 547
    Tcp11; T-complex protein 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    6128001..6140152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601645.3 → XP_017457134.1  T-complex protein 11 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6GK20, A6JJP5
    Related
    ENSRNOP00000092987.1, ENSRNOT00000109959.2
    Conserved Domains (1) summary
    pfam05794
    Location:64 → 468
    Tcp11; T-complex protein 11

  2. XM_017601644.3 → XP_017457133.1  T-complex protein 11 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q5XI00
    UniProtKB/TrEMBL
    A6JJP5
    Conserved Domains (1) summary
    pfam05794
    Location:143 → 547
    Tcp11; T-complex protein 11

  3. XM_006256200.5 → XP_006256262.1  T-complex protein 11 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I6GK20, A6JJP5
    Conserved Domains (1) summary
    pfam05794
    Location:64 → 468
    Tcp11; T-complex protein 11

  4. XM_063279128.1 → XP_063135198.1  T-complex protein 11 homolog isoform X2

    UniProtKB/TrEMBL
    A6JJP5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI00.1 GenPept UniProtKB/Swiss-Prot:Q5XI00

Gene LinkOut

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