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Rrp1b ribosomal RNA processing 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 309673, updated on 27-Nov-2024

Summary

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Official Symbol
Rrp1bprovided by RGD
Official Full Name
ribosomal RNA processing 1Bprovided by RGD
Primary source
RGD:1305633
See related
EnsemblRapid:ENSRNOG00000001194 AllianceGenome:RGD:1305633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305633
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in several processes, including cellular response to virus; negative regulation of GTPase activity; and regulation of gene expression. Predicted to be located in chromatin and nuclear lumen. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in nucleus. Orthologous to human RRP1B (ribosomal RNA processing 1B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 43.3), Spleen (RPKM 40.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rrp1b in Genome Data Viewer
Location:
20p12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (10122825..10148404)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (10123111..10148704)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10844234..10869830)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098852 Neighboring gene heat shock transcription factor 2 binding protein Neighboring gene pyridoxal kinase like 1 Neighboring gene pyridoxal kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription. Su WC, et al. J Virol, 2015 Nov. PMID 26311876, Free PMC Article
  2. Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. Crawford NP, et al. PLoS Genet, 2007 Nov. PMID 18081427, Free PMC Article
  3. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. Paik JC, et al. J Biol Chem, 2010 Feb 26. PMID 20040599, Free PMC Article
  4. RRP1B is a metastasis modifier that regulates the expression of alternative mRNA isoforms through interactions with SRSF1. Lee M, et al. Oncogene, 2014 Apr 3. PMID 23604122, Free PMC Article
  5. RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. Chamousset D, et al. Mol Biol Cell, 2010 Dec. PMID 20926688, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
  
located_in granular component ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal RNA processing protein 1 homolog B
Names
ribosomal RNA processing 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427282.1 → NP_001414211.1  ribosomal RNA processing protein 1 homolog B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    Related
    ENSRNOP00000001583.8, ENSRNOT00000001583.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    10122825..10148404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601874.3 → XP_017457363.1  ribosomal RNA processing protein 1 homolog B isoform X1

    UniProtKB/TrEMBL
    D3ZY39
    Conserved Domains (1) summary
    pfam05997
    Location:2 → 148
    Nop52; Nucleolar protein,Nop52
Nucleotide Protein Strain
Heading Accession and Version

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