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Ascc3 activating signal cointegrator 1 complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309887, updated on 27-Nov-2024

Summary

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Official Symbol
Ascc3provided by RGD
Official Full Name
activating signal cointegrator 1 complex subunit 3provided by RGD
Primary source
RGD:1307995
See related
AllianceGenome:RGD:1307995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Helic1
Summary
Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in several processes, including DNA alkylation repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and activating signal cointegrator 1 complex. Predicted to be active in cytosolic ribosome and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 176.9), Adrenal (RPKM 155.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ascc3 in Genome Data Viewer
Location:
20q13
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (55089430..55372374)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (53510137..53795446)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (55253670..55557249)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha 1-like Neighboring gene sperm motility kinase like, pseudogene 8 Neighboring gene uncharacterized LOC134483837 Neighboring gene SIM bHLH transcription factor 1 Neighboring gene lysophospholipase 1, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. Dango S, et al. Mol Cell, 2011 Nov 4. PMID 22055184, Free PMC Article
  2. Novel transcription coactivator complex containing activating signal cointegrator 1. Jung DJ, et al. Mol Cell Biol, 2002 Jul. PMID 12077347, Free PMC Article
  3. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189522

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA alkylation repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA duplex unwinding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
  
part_of activating signal cointegrator 1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1 complex subunit 3
Names
helicase, ATP binding 1
NP_001263986.1
XP_006256664.1
XP_006256665.1
XP_008771214.1
XP_008771215.1
XP_038954701.1
XP_063135250.1
XP_063135251.1
XP_063135253.1
XP_063135254.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277057.1 → NP_001263986.1  activating signal cointegrator 1 complex subunit 3

    See identical proteins and their annotated locations for NP_001263986.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    55089430..55372374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279181.1 → XP_063135251.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MY43

  2. XM_063279180.1 → XP_063135250.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MY43

  3. XM_006256602.5 → XP_006256664.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_006256664.1

    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

  4. XM_063279184.1 → XP_063135254.1  activating signal cointegrator 1 complex subunit 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZWJ5

  5. XM_008772992.4 → XP_008771214.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_008771214.1

    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

  6. XM_006256603.5 → XP_006256665.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_006256665.1

    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

  7. XM_039098773.2 → XP_038954701.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

  8. XM_063279183.1 → XP_063135253.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    UniProtKB/TrEMBL
    A0A0A0MY43

  9. XM_008772993.4 → XP_008771215.1  activating signal cointegrator 1 complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_008771215.1

    UniProtKB/TrEMBL
    A0A0A0MY43, A6K6T5
    Conserved Domains (2) summary
    COG1204
    Location:478 → 1240
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    cd18022
    Location:1327 → 1515
    DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

RNA

  1. XR_010060704.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107640.1: Suppressed sequence

    Description
    NM_001107640.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LPQ2.1 GenPept UniProtKB/Swiss-Prot:F1LPQ2

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials