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Rhobtb3 Rho-related BTB domain containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309922, updated on 27-Nov-2024

Summary

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Official Symbol
Rhobtb3provided by RGD
Official Full Name
Rho-related BTB domain containing 3provided by RGD
Primary source
RGD:1311683
See related
EnsemblRapid:ENSRNOG00000012414 AllianceGenome:RGD:1311683
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and enzyme binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within male gonad development. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human RHOBTB3 (Rho related BTB domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 150.3), Liver (RPKM 109.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhobtb3 in Genome Data Viewer
Location:
2q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (7094972..7201507, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (5363388..5419164, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (2627655..2683305, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase kappa 1-like Neighboring gene glutaredoxin Neighboring gene small nucleolar RNA SNORA17 Neighboring gene spermatogenesis associated 9 Neighboring gene Rieske (Fe-S) domain containing Neighboring gene G protein-coupled receptor 150

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport. Espinosa EJ, et al. Cell, 2009 May 29. PMID 19490898, Free PMC Article
  2. Expression analysis of mouse Rhobtb3 using a LacZ reporter and preliminary characterization of a knockout strain. Lutz J, et al. Histochem Cell Biol, 2014 Nov. PMID 24923387
  3. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within male gonad development ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-related BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107645.1 → NP_001101115.1  rho-related BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_001101115.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473955
    UniProtKB/TrEMBL
    A6I4F2, A6I4F3, D3ZW90
    Related
    ENSRNOP00000016838.5, ENSRNOT00000016838.8
    Conserved Domains (3) summary
    smart00225
    Location:421 → 518
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:413 → 515
    BTB; BTB/POZ domain
    cl21455
    Location:34 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    7094972..7201507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281692.1 → XP_063137762.1  rho-related BTB domain-containing protein 3 isoform X2

  2. XM_039102150.2 → XP_038958078.1  rho-related BTB domain-containing protein 3 isoform X1

    Conserved Domains (3) summary
    cd18357
    Location:236 → 393
    BTB1_POZ_RHOBTB3; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3)
    cl38908
    Location:410 → 428
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl38936
    Location:34 → 174
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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