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Utp15 UTP15, small subunit processome component [ Rattus norvegicus (Norway rat) ]

Gene ID: 310019, updated on 27-Nov-2024

Summary

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Official Symbol
Utp15provided by RGD
Official Full Name
UTP15, small subunit processome componentprovided by RGD
Primary source
RGD:1310992
See related
EnsemblRapid:ENSRNOG00000016591 AllianceGenome:RGD:1310992
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310992
Summary
Predicted to be involved in positive regulation of RNA metabolic process and ribosome biogenesis. Predicted to be located in endoplasmic reticulum and fibrillar center. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP15 (UTP15 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 66.6), Spleen (RPKM 57.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Utp15 in Genome Data Viewer
Location:
2q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (31329222..31347022, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (29594405..29612819, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (28351925..28370315, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene Rho guanine nucleotide exchange factor 28 Neighboring gene uncharacterized LOC134485583 Neighboring gene ankyrin repeat family A member 2 Neighboring gene basic transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction, mobility, and phosphorylation of human orthologues of WD repeat-containing components of the yeast SSU processome t-UTP sub-complex. Sato M, et al. Biochem Cell Biol, 2013 Dec. PMID 24219289
  2. Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells. Prieto JL, et al. Genes Dev, 2007 Aug 15. PMID 17699751, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 15 homolog
Names
UTP15 SSU processome component
UTP15, U3 small nucleolar ribonucleoprotein, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107647.2 → NP_001101117.1  U3 small nucleolar RNA-associated protein 15 homolog

    Status: PROVISIONAL

    Source sequence(s)
    BC131851
    UniProtKB/Swiss-Prot
    A2RRU3
    UniProtKB/TrEMBL
    A0A8I6B2C6, A6I536
    Related
    ENSRNOP00000095293.2, ENSRNOT00000097680.2
    Conserved Domains (3) summary
    cd00200
    Location:39 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:41 → 78
    7WD40; WD40 repeat [structural motif]
    pfam09384
    Location:344 → 490
    UTP15_C; UTP15 C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    31329222..31347022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102170.2 → XP_038958098.1  U3 small nucleolar RNA-associated protein 15 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2RRU3
    UniProtKB/TrEMBL
    A0A8I6B2C6, A6I536
    Conserved Domains (3) summary
    cd00200
    Location:39 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:41 → 78
    7WD40; WD40 repeat [structural motif]
    pfam09384
    Location:344 → 490
    UTP15_C; UTP15 C terminal

  2. XM_063281718.1 → XP_063137788.1  U3 small nucleolar RNA-associated protein 15 homolog isoform X1

    UniProtKB/Swiss-Prot
    A2RRU3
    UniProtKB/TrEMBL
    A6I536
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RRU3.1 GenPept UniProtKB/Swiss-Prot:A2RRU3

Gene LinkOut

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