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Vsp37A Vacuolar protein sorting 37A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31006, updated on 4-Jan-2025

Summary

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Official Symbol
Vsp37Aprovided by FlyBase
Official Full Name
Vacuolar protein sorting 37Aprovided by FlyBase
Primary source
FLYBASE:FBgn0016038
Locus tag
Dmel_CG17828
See related
AllianceGenome:FB:FBgn0016038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.78; CG17828; Dmel\CG17828; EG:115C2.5; mod(r); Vps37; vps37A
Summary
Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Vsp37A in Genome Data Viewer
Location:
1B12-1B12; 1-0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (621530..623051)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (515563..517084)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45474 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45475 Neighboring gene uncharacterized protein Neighboring gene Histone H4 transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modifier of rudimentary p1, mod(r)p1, a trans-acting regulatory mutation of rudimentary. Begley D, et al. Mol Gen Genet, 1995 Jul 22. PMID 7651329
  2. The Endosomal Sorting Complex, ESCRT, has diverse roles in blood progenitor maintenance, lineage choice and immune response. Ray A, et al. Biol Open, 2024 Jun 15. PMID 38828842, Free PMC Article
  3. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. Vaccari T, et al. J Cell Sci, 2009 Jul 15. PMID 19571114, Free PMC Article
  4. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450
  5. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mattissek C, et al. Mol Membr Biol, 2014 Jun. PMID 24641493, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
vacuolar protein sorting 37A
Names
CG17828-PA
CG17828-PB
CG17828-PC
CG17828-PD
CG17828-PE
CG17828-PF
Vsp37A-PA
Vsp37A-PB
Vsp37A-PC
Vsp37A-PD
Vsp37A-PE
Vsp37A-PF
modifier of rudimentary

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    621530..623051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080295.3 → NP_525034.2  vacuolar protein sorting 37A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525034.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77259, Q9N6W9
    Related
    FBpp0088667
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 181
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  2. NM_166850.2 → NP_726681.1  vacuolar protein sorting 37A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726681.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZA5, Q9N6W9
    Related
    FBpp0088665
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 177
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  3. NM_166848.2 → NP_726679.1  vacuolar protein sorting 37A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77259, Q9N6W9
    Related
    FBpp0088666
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 181
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  4. NM_001272172.1 → NP_001259101.1  vacuolar protein sorting 37A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77259, Q9N6W9
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 181
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  5. NM_001272171.1 → NP_001259100.1  vacuolar protein sorting 37A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259100.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZA5, Q9N6W9
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 177
    Mod_r; Modifier of rudimentary (Mod(r)) protein

  6. NM_166849.2 → NP_726680.1  vacuolar protein sorting 37A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726680.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YZA5, Q9N6W9
    Related
    FBpp0088664
    Conserved Domains (1) summary
    pfam07200
    Location:42 → 177
    Mod_r; Modifier of rudimentary (Mod(r)) protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77259 O77259
Q7YZA5 Q7YZA5
Q9N6W9 Q9N6W9

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