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Mtmr12 myotubularin related protein 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310155, updated on 4-Jan-2025

Summary

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Official Symbol
Mtmr12provided by RGD
Official Full Name
myotubularin related protein 12provided by RGD
Primary source
RGD:1307902
See related
EnsemblRapid:ENSRNOG00000022929 AllianceGenome:RGD:1307902
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pip3ap
Summary
Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in sarcomere and sarcoplasmic reticulum. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR12 (myotubularin related protein 12). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 146.6), Kidney (RPKM 129.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtmr12 in Genome Data Viewer
Location:
2q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62950722..63020319)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61223714..61293270)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62236497..62305995)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger RNA binding protein Neighboring gene uncharacterized LOC134485602 Neighboring gene uncharacterized LOC120101086 Neighboring gene golgi phosphoprotein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
  2. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article
  3. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC109012

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myotubularin-related protein 12
Names
inactive phosphatidylinositol 3-phosphatase 12
phosphatidylinositol 3-phosphatase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012077.2 → NP_001012077.1  myotubularin-related protein 12 isoform 2

    See identical proteins and their annotated locations for NP_001012077.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5FVM6
    Conserved Domains (2) summary
    cl17171
    Location:26 → 192
    PH-like; Pleckstrin homology-like domain
    cl21483
    Location:211 → 497
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001415035.1 → NP_001401964.1  myotubularin-related protein 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q5FVM6
    UniProtKB/TrEMBL
    A0A8L2QJ51
    Related
    ENSRNOP00000036677.3, ENSRNOT00000036633.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    62950722..63020319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102201.2 → XP_038958129.1  myotubularin-related protein 12 isoform X3

    UniProtKB/TrEMBL
    A6KJQ2
    Conserved Domains (2) summary
    cd14594
    Location:57 → 259
    PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
    pfam12578
    Location:358 → 482
    3-PAP; Myotubularin-associated protein

  2. XM_017590832.3 → XP_017446321.1  myotubularin-related protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QJ51

  3. XM_039102200.2 → XP_038958128.1  myotubularin-related protein 12 isoform X2

    Conserved Domains (3) summary
    cd14594
    Location:109 → 311
    PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
    pfam12578
    Location:410 → 534
    3-PAP; Myotubularin-associated protein
    cl17171
    Location:14 → 40
    PH-like; Pleckstrin homology-like domain

  4. XM_039102202.2 → XP_038958130.1  myotubularin-related protein 12 isoform X3

    UniProtKB/TrEMBL
    A6KJQ2
    Conserved Domains (2) summary
    cd14594
    Location:57 → 259
    PTP-MTMR12; protein tyrosine phosphatase-like pseudophosphatase domain of myotubularin related phosphoinositide phosphatase 12
    pfam12578
    Location:358 → 482
    3-PAP; Myotubularin-associated protein

  5. XM_039102203.2 → XP_038958131.1  myotubularin-related protein 12 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZUA7
    Related
    ENSRNOP00000082096.1, ENSRNOT00000114002.2
    Conserved Domains (2) summary
    pfam12578
    Location:234 → 358
    3-PAP; Myotubularin-associated protein
    cl28904
    Location:2 → 135
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVM6.2 GenPept UniProtKB/Swiss-Prot:Q5FVM6

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