U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Usp13 ubiquitin specific peptidase 13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310306, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Usp13provided by RGD
Official Full Name
ubiquitin specific peptidase 13provided by RGD
Primary source
RGD:1306044
See related
EnsemblRapid:ENSRNOG00000030639 AllianceGenome:RGD:1306044
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including BAT3 complex binding activity; peptidase activity; and proteasome binding activity. Predicted to be involved in several processes, including maintenance of unfolded protein; positive regulation of ERAD pathway; and regulation of autophagy. Predicted to act upstream of or within protein deubiquitination and protein stabilization. Predicted to be active in cytosol and nucleus. Orthologous to human USP13 (ubiquitin specific peptidase 13). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 616.4), Heart (RPKM 493.7) and 2 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Usp13 in Genome Data Viewer
Location:
2q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (117502811..117617049)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115576912..115689153)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (119197153..119317507)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene mitochondrial ribosomal protein L47 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 Neighboring gene peroxisomal biogenesis factor 5-like Neighboring gene uncharacterized LOC134485614 Neighboring gene uncharacterized LOC134485613

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. USP13 reduces septic mediated cardiomyocyte oxidative stress and inflammation by inducing Nrf2. Wu D, et al. Allergol Immunopathol (Madr), 2023. PMID 36916102
  2. Regulation of MITF stability by the USP13 deubiquitinase. Zhao X, et al. Nat Commun, 2011 Aug 2. PMID 21811243
  3. USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains. Scortegagna M, et al. J Biol Chem, 2011 Aug 5. PMID 21659512, Free PMC Article
  4. Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin. Zhang YH, et al. PLoS One, 2011. PMID 22216260, Free PMC Article
  5. Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Liu J, et al. Cell, 2011 Sep 30. PMID 21962518, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP13 reduces septic mediated cardiomyocyte oxidative stress and inflammation by inducing Nrf2.
    Title: USP13 reduces septic mediated cardiomyocyte oxidative stress and inflammation by inducing Nrf2.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BAT3 complex binding ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of unfolded protein ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein K29-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein K6-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 13
Names
ubiquitin specific protease 13 (isopeptidase T-3)
ubiquitin thiolesterase 13
NP_001101135.1
XP_008759146.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107665.2 → NP_001101135.1  ubiquitin carboxyl-terminal hydrolase 13

    See identical proteins and their annotated locations for NP_001101135.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6IHR3, D3ZDI9
    Related
    ENSRNOP00000039985.4, ENSRNOT00000048030.7
    Conserved Domains (2) summary
    COG5207
    Location:28 → 856
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:335 → 854
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    117502811..117617049
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760924.4 → XP_008759146.1  ubiquitin carboxyl-terminal hydrolase 13 isoform X1

    Related
    ENSRNOP00000108074.1, ENSRNOT00000157346.1
    Conserved Domains (5) summary
    COG5207
    Location:28 → 855
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02658
    Location:334 → 853
    Peptidase_C19B; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14384
    Location:649 → 697
    UBA1_UBP13; UBA1 domain found in ubiquitin carboxyl-terminal hydrolase 13 (UBP13)
    cd14386
    Location:722 → 763
    UBA2_UBP5; UBA2 domain found in ubiquitin carboxyl-terminal hydrolase 5 (UBP5)
    pfam02148
    Location:208 → 281
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous