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Ubqln4 ubiquilin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310633, updated on 27-Nov-2024

Summary

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Official Symbol
Ubqln4provided by RGD
Official Full Name
ubiquilin 4provided by RGD
Primary source
RGD:1308273
See related
EnsemblRapid:ENSRNOG00000019933 AllianceGenome:RGD:1308273
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1308273
Summary
Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of autophagosome maturation; negative regulation of double-strand break repair via homologous recombination; and regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including autophagosome; endoplasmic reticulum membrane; and site of DNA damage. Predicted to be part of cytosolic proteasome complex and nuclear proteasome complex. Predicted to be active in cytosol. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 168.4), Thymus (RPKM 165.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ubqln4 in Genome Data Viewer
Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176310524..176325724)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174012726..174028062)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187915701..187931035)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member A Neighboring gene RAB25, member RAS oncogene family Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized LOC134485638 Neighboring gene signal sequence receptor subunit 2 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up. Riley BE, et al. J Biol Chem, 2004 Oct 1. PMID 15280365
  2. UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation. Suzuki R, et al. EMBO Rep, 2016 Jun. PMID 27113755, Free PMC Article
  3. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein. Davidson JD, et al. Hum Mol Genet, 2000 Sep 22. PMID 11001934
  4. UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Jachimowicz RD, et al. Cell, 2019 Jan 24. PMID 30612738
  5. Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. Matsuda M, et al. Biochem Biophys Res Commun, 2001 Jan 19. PMID 11162551

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43
    Title: A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of autophagosome maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear proteasome complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquilin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107688.1 → NP_001101158.1  ubiquilin-4

    See identical proteins and their annotated locations for NP_001101158.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473976
    UniProtKB/TrEMBL
    A6J690, D4A3P1
    Related
    ENSRNOP00000026994.4, ENSRNOT00000026994.9
    Conserved Domains (4) summary
    smart00727
    Location:186 → 223
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:13 → 83
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:13 → 83
    UBQ; Ubiquitin homologues
    cd14399
    Location:552 → 591
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    176310524..176325724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281838.1 → XP_063137908.1  ubiquilin-4 isoform X2

  2. XM_006232642.4 → XP_006232704.1  ubiquilin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1E6
    Related
    ENSRNOP00000086536.1, ENSRNOT00000092752.3
    Conserved Domains (4) summary
    smart00727
    Location:186 → 223
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:13 → 83
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:13 → 83
    UBQ; Ubiquitin homologues
    cd14399
    Location:499 → 538
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

  3. XM_039102310.2 → XP_038958238.1  ubiquilin-4 isoform X3

    Conserved Domains (2) summary
    cd14399
    Location:310 → 349
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl17974
    Location:129 → 165
    STI1; STI1 domain

  4. XM_039102311.2 → XP_038958239.1  ubiquilin-4 isoform X4

    Conserved Domains (2) summary
    cd14399
    Location:263 → 302
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl17974
    Location:82 → 118
    STI1; STI1 domain
Nucleotide Protein Strain
Heading Accession and Version

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