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Mindy1 MINDY lysine 48 deubiquitinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310665, updated on 27-Nov-2024

Summary

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Official Symbol
Mindy1provided by RGD
Official Full Name
MINDY lysine 48 deubiquitinase 1provided by RGD
Primary source
RGD:1559660
See related
EnsemblRapid:ENSRNOG00000021131 AllianceGenome:RGD:1559660
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fam63a
Summary
Predicted to enable K48-linked deubiquitinase activity; K48-linked polyubiquitin modification-dependent protein binding activity; and cysteine-type carboxypeptidase activity. Predicted to be involved in chromatin remodeling and proteolysis. Predicted to be located in nuclear body. Orthologous to human MINDY1 (MINDY lysine 48 deubiquitinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 167.3), Kidney (RPKM 109.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mindy1 in Genome Data Viewer
Location:
2q34
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185550026..185561987)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182859977..182873000)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196458229..196470133)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein like Neighboring gene prune exopolyphosphatase 1 Neighboring gene annexin A9 Neighboring gene ceramide synthase 2 Neighboring gene SET domain bifurcated histone lysine methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Abdul Rehman SA, et al. Mol Cell, 2016 Jul 7. PMID 27292798, Free PMC Article
  2. A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains. Kristariyanto YA, et al. EMBO Rep, 2017 Mar. PMID 28082312, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC109471

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K48-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase MINDY-1
Names
deubiquitinating enzyme MINDY-1
family with sequence similarity 63, member A
protein FAM63A
NP_001020289.1
XP_017446390.1
XP_038958280.1
XP_038958281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025118.1 → NP_001020289.1  ubiquitin carboxyl-terminal hydrolase MINDY-1

    See identical proteins and their annotated locations for NP_001020289.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091386
    UniProtKB/Swiss-Prot
    Q5BJQ2
    Conserved Domains (1) summary
    pfam04424
    Location:158 → 275
    MINDY_DUB; MINDY deubiquitinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185550026..185561987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590901.3 → XP_017446390.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5BJQ2
    Conserved Domains (1) summary
    pfam04424
    Location:158 → 275
    MINDY_DUB; MINDY deubiquitinase

  2. XM_039102353.2 → XP_038958281.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

    Related
    ENSRNOP00000053218.3, ENSRNOT00000056380.5
    Conserved Domains (1) summary
    pfam04424
    Location:158 → 275
    MINDY_DUB; MINDY deubiquitinase

  3. XM_039102352.2 → XP_038958280.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

    UniProtKB/Swiss-Prot
    Q5BJQ2
    Conserved Domains (1) summary
    pfam04424
    Location:158 → 275
    MINDY_DUB; MINDY deubiquitinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BJQ2.1 GenPept UniProtKB/Swiss-Prot:Q5BJQ2

Gene LinkOut

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