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CG3638 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31071, updated on 4-Jan-2025

Summary

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Official Symbol
CG3638provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261444
Locus tag
Dmel_CG3638
See related
AllianceGenome:FB:FBgn0261444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG00376; Dmel\CG3638; EG:33C11.3; TTYH2
Summary
Predicted to enable intracellularly calcium-gated chloride channel activity and volume-sensitive chloride channel activity. Predicted to be involved in chloride transport. Located in plasma membrane. Is expressed in adult head. Orthologous to human TTYH1 (tweety family member 1); TTYH2 (tweety family member 2); and TTYH3 (tweety family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG3638 in Genome Data Viewer
Location:
1E4-1E5; 1-0.1 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1215289..1236684, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1109322..1130717, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Activating transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels. Suzuki M. Exp Physiol, 2006 Jan. PMID 16219661
  2. A microRNA that controls the emergence of embryonic movement. Menzies JAC, et al. Elife, 2024 Jun 13. PMID 38869942, Free PMC Article
  3. The exon junction complex differentially marks spliced junctions. Saulière J, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818392
  4. Mutations in many genes affect aggressive behavior in Drosophila melanogaster. Edwards AC, et al. BMC Biol, 2009 Jun 11. PMID 19519879, Free PMC Article
  5. Quantitative trait loci affecting starvation resistance in Drosophila melanogaster. Harbison ST, et al. Genetics, 2004 Apr. PMID 15126400, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables volume-sensitive chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
BG00376
CG3638-PB
CG3638-PF
CG3638-PG
CG3638-PH
CG3638-PI
CG3638-PJ
CG3638-PK
CG3638-PL
tweety-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1215289..1236684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166874.3 → NP_726722.1  uncharacterized protein Dmel_CG3638, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8WHI0, O97175, Q8IRY1, Q8IRY2, Q8IRY3, Q9U1L5, Q9W5A5
    Related
    FBpp0307920
    Conserved Domains (1) summary
    cl12141
    Location:36 → 448
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  2. NM_166873.3 → NP_726721.1  uncharacterized protein Dmel_CG3638, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726721.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEN6
    Related
    FBpp0070239
    Conserved Domains (1) summary
    pfam04906
    Location:21 → 432
    Tweety; Tweety

  3. NM_130541.4 → NP_569897.4  uncharacterized protein Dmel_CG3638, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569897.4

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam04906
    Location:21 → 432
    Tweety; Tweety

  4. NM_001316632.1 → NP_001303561.1  uncharacterized protein Dmel_CG3638, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0X0Z7
    Conserved Domains (1) summary
    cd07912
    Location:1 → 421
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  5. NM_001272195.1 → NP_001259124.1  uncharacterized protein Dmel_CG3638, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGE0
    Conserved Domains (1) summary
    cd07912
    Location:1 → 421
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  6. NM_001258531.2 → NP_001245460.1  uncharacterized protein Dmel_CG3638, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245460.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEN6
    Conserved Domains (1) summary
    pfam04906
    Location:21 → 432
    Tweety; Tweety

  7. NM_166872.3 → NP_726720.3  uncharacterized protein Dmel_CG3638, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726720.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W5A5
    Conserved Domains (1) summary
    cd07912
    Location:1 → 421
    Tweety_N; N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels

  8. NM_001316631.1 → NP_001303560.1  uncharacterized protein Dmel_CG3638, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0X7W8
    Conserved Domains (1) summary
    pfam04906
    Location:21 → 432
    Tweety; Tweety
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0X0Z7 A0A0S0X0Z7
A0A0S0X7W8 A0A0S0X7W8
M9NEN6 M9NEN6
M9PGE0 M9PGE0
Q8MRZ6 Q8MRZ6
Q9W5A5.2 Q9W5A5

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