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Ap4b1 adaptor related protein complex 4 subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310746, updated on 2-Nov-2024

Summary

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Official Symbol
Ap4b1provided by RGD
Official Full Name
adaptor related protein complex 4 subunit beta 1provided by RGD
Primary source
RGD:1310529
See related
EnsemblRapid:ENSRNOG00000019455 AllianceGenome:RGD:1310529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable clathrin binding activity. Predicted to be involved in protein localization to somatodendritic compartment; protein targeting; and vesicle-mediated transport. Predicted to be located in cytoplasmic side of trans-Golgi network transport vesicle membrane; cytosol; and trans-Golgi network. Predicted to be part of AP-4 adaptor complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 47. Orthologous to human AP4B1 (adaptor related protein complex 4 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 135.2), Spleen (RPKM 98.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap4b1 in Genome Data Viewer
Location:
2q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194006926..194018971)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (191318485..191330531)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (206293679..206305705)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene uncharacterized LOC108350077 Neighboring gene DNA cross-link repair 1B Neighboring gene Bcl2-like 15 Neighboring gene ribosomal protein L36A, pseudogene 15 Neighboring gene protein tyrosine phosphatase, non-receptor type 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a fourth adaptor-related protein complex. Hirst J, et al. Mol Biol Cell, 1999 Aug. PMID 10436028, Free PMC Article
  2. AP-4, a novel protein complex related to clathrin adaptors. Dell'Angelica EC, et al. J Biol Chem, 1999 Mar 12. PMID 10066790
  3. Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4. Matsuda S, et al. Neuron, 2008 Mar 13. PMID 18341993
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to somatodendritic compartment ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-4 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of trans-Golgi network transport vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-4 complex subunit beta-1
Names
adaptor-related protein complex 4, beta 1 subunit
adaptor-related protein complex AP-4, beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107709.1 → NP_001101179.1  AP-4 complex subunit beta-1

    See identical proteins and their annotated locations for NP_001101179.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474015
    UniProtKB/TrEMBL
    A0A8I6A896, A0A8I6AM43, A6K3M9
    Conserved Domains (3) summary
    sd00044
    Location:86 → 113
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:9 → 525
    Adaptin_N; Adaptin N terminal region
    pfam09066
    Location:621 → 730
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    194006926..194018971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590915.2 → XP_017446404.1  AP-4 complex subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A896, A0A8I6AM43, A6K3M9
    Conserved Domains (3) summary
    sd00044
    Location:86 → 113
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:9 → 525
    Adaptin_N; Adaptin N terminal region
    pfam09066
    Location:621 → 730
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

  2. XM_006233081.5 → XP_006233143.1  AP-4 complex subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006233143.1

    UniProtKB/TrEMBL
    A0A8I6A896, A0A8I6AM43, A6K3M9
    Related
    ENSRNOP00000087320.1, ENSRNOT00000112010.2
    Conserved Domains (3) summary
    sd00044
    Location:86 → 113
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:9 → 525
    Adaptin_N; Adaptin N terminal region
    pfam09066
    Location:621 → 730
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

  3. XM_063281908.1 → XP_063137978.1  AP-4 complex subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    D4AD35
    Related
    ENSRNOP00000026382.5, ENSRNOT00000026382.7

  4. XM_063281909.1 → XP_063137979.1  AP-4 complex subunit beta-1 isoform X4

  5. XM_063281910.1 → XP_063137980.1  AP-4 complex subunit beta-1 isoform X5

  6. XM_039102411.2 → XP_038958339.1  AP-4 complex subunit beta-1 isoform X6

    Conserved Domains (2) summary
    sd00044
    Location:86 → 113
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:9 → 401
    Adaptin_N; Adaptin N terminal region

  7. XM_039102410.1 → XP_038958338.1  AP-4 complex subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GCJ1
    Related
    ENSRNOP00000085168.1, ENSRNOT00000112580.2
    Conserved Domains (2) summary
    smart01020
    Location:414 → 526
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:4 → 319
    Adaptin_N; Adaptin N terminal region

  8. XM_039102409.2 → XP_038958337.1  AP-4 complex subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GCJ1
    Conserved Domains (2) summary
    smart01020
    Location:414 → 526
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    pfam01602
    Location:4 → 319
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein Strain
Heading Accession and Version

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