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Naa30A N(alpha)-acetyltransferase 30 A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31079, updated on 4-Jan-2025

Summary

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Official Symbol
Naa30Aprovided by FlyBase
Official Full Name
N(alpha)-acetyltransferase 30 Aprovided by FlyBase
Primary source
FLYBASE:FBgn0024362
Locus tag
Dmel_CG11412
See related
AllianceGenome:FB:FBgn0024362
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg11412; CG11412; DmAAF45606; Dmel\CG11412; EG:8D8.6; Naa30; NAA30
Summary
Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in N-terminal peptidyl-methionine acetylation. Part of NatC complex. Is expressed in organism. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Naa30A in Genome Data Viewer
Location:
1F3-1F4; 1-0.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1342106..1344770)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1236139..1238803)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene female sterile (1) Nasrat Neighboring gene uncharacterized protein Neighboring gene mitochondrial poly(A) polymerase Neighboring gene Tetraspanin 2A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. Polevoda B, et al. J Mol Biol, 2003 Jan 24. PMID 12507466
  2. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article
  3. Drosophila Embryos as a Model for Wound-Induced Transcriptional Dynamics: Genetic Strategies to Achieve a Localized Wound Response. Juarez MT. Adv Wound Care (New Rochelle), 2016 Jun 1. PMID 27274436, Free PMC Article
  4. Novel function of N-acetyltransferase for microtubule stability and JNK signaling in Drosophila organ development. Mok JW, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 33479178, Free PMC Article
  5. Duox, Flotillin-2, and Src42A are required to activate or delimit the spread of the transcriptional response to epidermal wounds in Drosophila. Juarez MT, et al. PLoS Genet, 2011 Dec. PMID 22242003, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N(alpha)-acetyltransferase 30 A
Names
CG11412-PA
CG11412-PD
N(alpha)-acetyltransferase 30
Naa30A-PA
Naa30A-PD
NP_001259128.1
NP_726727.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1342106..1344770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166878.3 → NP_726727.1  N(alpha)-acetyltransferase 30 A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726727.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46309, Q95RC0, Q9W5A3
    UniProtKB/TrEMBL
    E8NH31
    Related
    FBpp0070202
    Conserved Domains (2) summary
    TIGR01575
    Location:242 → 370
    rimI; ribosomal-protein-alanine acetyltransferase
    pfam00583
    Location:276 → 354
    Acetyltransf_1; Acetyltransferase (GNAT) family

  2. NM_001272199.2 → NP_001259128.1  N(alpha)-acetyltransferase 30 A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH31, M9PGL2
    Conserved Domains (2) summary
    TIGR01575
    Location:223 → 351
    rimI; ribosomal-protein-alanine acetyltransferase
    pfam00583
    Location:257 → 335
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGL2 M9PGL2
Q95RC0.1 Q95RC0

Gene LinkOut

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