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Tsp2A Tetraspanin 2A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31080, updated on 9-Dec-2024

Summary

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Official Symbol
Tsp2Aprovided by FlyBase
Official Full Name
Tetraspanin 2Aprovided by FlyBase
Primary source
FLYBASE:FBgn0024361
Locus tag
Dmel_CG11415
See related
AllianceGenome:FB:FBgn0024361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11415; D8.7; Dm.Tsp2A; Dmel\CG11415; EG:8D8.7; tsp2a; tsp2A; Tsp2a
Summary
Involved in establishment of endothelial barrier; glial cell migration; and smooth septate junction assembly. Located in apicolateral plasma membrane and smooth septate junction. Is expressed in several structures, including embryonic/larval hemocyte; epithelium; ganglia; gut section; and somatic precursor cell. Human ortholog(s) of this gene implicated in retinitis pigmentosa 7. Orthologous to human ROM1 (retinal outer segment membrane protein 1); TSPAN10 (tetraspanin 10); and TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Tsp2A in Genome Data Viewer
Location:
1F4-1F4; 1-0.1 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1346553..1348143)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1240586..1242176)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene N(alpha)-acetyltransferase 30 A Neighboring gene mitochondrial poly(A) polymerase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Septate junctions regulate gut homeostasis through regulation of stem cell proliferation and enterocyte behavior in Drosophila. Izumi Y, et al. J Cell Sci, 2019 Sep 26. PMID 31444286
  2. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster. Beyenbach KW, et al. Am J Physiol Cell Physiol, 2020 Jun 1. PMID 32267718, Free PMC Article
  3. Gut tumors in flies alter the taste valence of an anti-tumorigenic bitter compound. Leung NY, et al. Curr Biol, 2024 Jun 17. PMID 38823383,
  4. The novel membrane protein Hoka regulates septate junction organization and stem cell homeostasis in the Drosophila gut. Izumi Y, et al. J Cell Sci, 2021 Mar 26. PMID 33589496
  5. A tetraspanin regulates septate junction formation in Drosophila midgut. Izumi Y, et al. J Cell Sci, 2016 Mar 15. PMID 26848177

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster.
    Title: The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules in Drosophila melanogaster.
  2. Together with Tsp2A, Ssk and Mesh form a protein complex, and all three proteins are required for smooth septate junctions (sSJs) formation, as well as intestinal barrier function.
    Title: Molecular dissection of smooth septate junctions: understanding their roles in arthropod physiology.
  3. Tsp2A regulates septate junction formation in Drosophila midgut.
    Title: A tetraspanin regulates septate junction formation in Drosophila midgut.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in smooth septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in smooth septate junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetraspanin 2A
Names
CG11415-PA
CG11415-PB
Tsp2A-PA
Tsp2A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1346553..1348143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080298.4 → NP_525037.1  tetraspanin 2A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525037.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46101
    Related
    FBpp0070204
    Conserved Domains (2) summary
    cd03127
    Location:116 → 204
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:18 → 232
    Tetraspannin; Tetraspanin family

  2. NM_001201594.2 → NP_001188523.1  tetraspanin 2A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188523.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46101
    Conserved Domains (2) summary
    cd03127
    Location:116 → 204
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:18 → 232
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46101.1 O46101

Gene LinkOut

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