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Rilpl Rab interacting lysosomal protein like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31090, updated on 14-Nov-2024

Summary

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Official Symbol
Rilplprovided by FlyBase
Official Full Name
Rab interacting lysosomal protein likeprovided by FlyBase
Primary source
FLYBASE:FBgn0024985
Locus tag
Dmel_CG11448
See related
AllianceGenome:FB:FBgn0024985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11448; Dmel\CG11448; EG:132E8.4; RILP
Summary
Enables GTP-dependent protein binding activity. Involved in lysosome localization. Located in lysosomal membrane and perinuclear region of cytoplasm. Is expressed in embryonic brain; larval nervous system; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 4. Orthologous to human RILPL1 (Rab interacting lysosomal protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Rilpl in Genome Data Viewer
Location:
2A1-2A1; 1-0.2 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1393054..1397337)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1287087..1291370)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene AMP-activated protein kinase alpha subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene futsch Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutional insights into the interaction between Rab7 and RILP in lysosome motility. Cui G, et al. iScience, 2023 Jul 21. PMID 37534141, Free PMC Article
  2. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Krzystek TJ, et al. Autophagy, 2023 Apr. PMID 36048753, Free PMC Article
  3. The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila. Rosa-Ferreira C, et al. Biol Open, 2018 Sep 5. PMID 30115618, Free PMC Article
  4. Rab2 drives axonal transport of dense core vesicles and lysosomal organelles. Lund VK, et al. Cell Rep, 2021 Apr 13. PMID 33852866
  5. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Edwards AC, et al. Genome Biol, 2009. PMID 19607677, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rab interacting lysosomal protein like
Names
CG11448-PA
CG11448-PB
CG11448-PC
Rilpl-PA
Rilpl-PB
Rilpl-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1393054..1397337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272203.1 → NP_001259132.1  Rab interacting lysosomal protein like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259132.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG81
    Conserved Domains (3) summary
    pfam09744
    Location:26 → 186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11315
    Location:239 → 315
    Med30; Mediator complex subunit 30
    pfam14662
    Location:114 → 314
    KASH_CCD; Coiled-coil region of CCDC155 or KASH

  2. NM_130554.3 → NP_569910.1  Rab interacting lysosomal protein like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569910.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76878
    Related
    FBpp0070216
    Conserved Domains (3) summary
    pfam09744
    Location:26 → 186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11315
    Location:239 → 315
    Med30; Mediator complex subunit 30
    pfam14662
    Location:114 → 314
    KASH_CCD; Coiled-coil region of CCDC155 or KASH

  3. NM_001272204.1 → NP_001259133.1  Rab interacting lysosomal protein like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGM0
    Conserved Domains (3) summary
    pfam09744
    Location:26 → 186
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam11315
    Location:239 → 315
    Med30; Mediator complex subunit 30
    pfam14662
    Location:114 → 314
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG81 M9PG81
M9PGM0 M9PGM0
O76878.1 O76878

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