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Usp33 ubiquitin specific peptidase 33 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310960, updated on 4-Jan-2025

Summary

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Official Symbol
Usp33provided by RGD
Official Full Name
ubiquitin specific peptidase 33provided by RGD
Primary source
RGD:1307848
See related
EnsemblRapid:ENSRNOG00000011294 AllianceGenome:RGD:1307848
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including cysteine-type peptidase activity; small GTPase binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including centrosome duplication; protein deubiquitination; and protein stabilization. Predicted to be located in several cellular components, including centrosome; focal adhesion; and neuronal cell body. Orthologous to human USP33 (ubiquitin specific peptidase 33). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 271.8), Brain (RPKM 265.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp33 in Genome Data Viewer
Location:
2q45
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (243938958..243988424)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241283209..241328479)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (257567179..257602817)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 256, pseudogene 2 Neighboring gene nexilin (F actin binding protein) Neighboring gene uncharacterized LOC120100974 Neighboring gene mitoguardin 1 Neighboring gene zinc finger, ZZ-type containing 3 Neighboring gene uncharacterized LOC134485695 Neighboring gene adenylate kinase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. Thorne C, et al. Traffic, 2011 Nov. PMID 21801292
  2. The solution structure of the ZnF UBP domain of USP33/VDU1. Allen MD, et al. Protein Sci, 2007 Sep. PMID 17766394, Free PMC Article
  3. Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain. Fekete C, et al. Endocrinology, 2007 Oct. PMID 17628004
  4. Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary. Zhang X, et al. Biol Trace Elem Res, 2016 Dec. PMID 27156111
  5. Midline crossing and Slit responsiveness of commissural axons require USP33. Yuasa-Kawada J, et al. Nat Neurosci, 2009 Sep. PMID 19684588, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High iodine intake had no discernible effects on USP20. Temporary increases in USP33 and USP19 mRNA levels were observed. The enzymes related to D2 ubiquitination change with prolonged high iodine intake. Increased D2 ubiquitination suppresses the activity of D2, causing a decrease in negative feedback of the hypothalamic-pituitary-thyroid axis.
    Title: Effect of Prolonged Iodine Overdose on Type 2 Iodothyronine Deiodinase Ubiquitination-Related Enzymes in the Rat Pituitary.
  2. Correlation between relative mRNA levels of WSB-1 and USP-33 in numerous tissues that do not express type 2 deiodinase(D2) suggests that these ubiquitin-related enzymes share additional substrates besides D2.
    Title: Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 33
Names
ubiquitin specific protease 33
NP_001401992.1
XP_038958425.1
XP_038958426.1
XP_063138059.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415063.1 → NP_001401992.1  ubiquitin carboxyl-terminal hydrolase 33

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6AEH4, F1LPJ7
    Related
    ENSRNOP00000060372.3, ENSRNOT00000066125.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    243938958..243988424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281989.1 → XP_063138059.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEH4, F1LPJ7

  2. XM_039102497.2 → XP_038958425.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEH4
    Conserved Domains (4) summary
    smart00695
    Location:799 → 883
    DUSP; Domain in ubiquitin-specific proteases
    pfam00443
    Location:153 → 671
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 89
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:693 → 762
    DUSP; DUSP domain

  3. XM_039102498.2 → XP_038958426.1  ubiquitin carboxyl-terminal hydrolase 33 isoform X3

    UniProtKB/TrEMBL
    A6HWL4
    Conserved Domains (3) summary
    pfam00443
    Location:153 → 679
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 89
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    cl12116
    Location:701 → 770
    DUSP; DUSP domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017379.1: Suppressed sequence

    Description
    NM_001017379.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.

  2. NM_001191094.1: Suppressed sequence

    Description
    NM_001191094.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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