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CG14777 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31099, updated on 4-Jan-2025

Summary

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Official Symbol
CG14777provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0026872
Locus tag
Dmel_CG14777
See related
AllianceGenome:FB:FBgn0026872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH63812; Dmel\CG14777; EG:80H7.10
Summary
Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head. Orthologous to human MPV17L (MPV17 mitochondrial inner membrane protein like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG14777 in Genome Data Viewer
Location:
2A4-2A4; 1-0.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1466134..1468692)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1360167..1362725)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleostemin 3 Neighboring gene O-fucosyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pickel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
  2. A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Kaplan DD, et al. Genes Dev, 2008 Jul 15. PMID 18628395, Free PMC Article
  3. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
  4. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638
  5. Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2018 Feb 2. PMID 29223976, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables monoatomic ion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14777-PB
CG14777-PC
CG14777-PD
CG14777-PE
CG14777-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1466134..1468692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297853.1 → NP_001284782.1  uncharacterized protein Dmel_CG14777, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284782.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W588, Q9XZT2
    Conserved Domains (1) summary
    pfam04117
    Location:118 → 181
    Mpv17_PMP22; Mpv17 / PMP22 family

  2. NM_130561.3 → NP_569917.1  uncharacterized protein Dmel_CG14777, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569917.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W588, Q9XZT2
    Related
    FBpp0070243
    Conserved Domains (1) summary
    pfam04117
    Location:118 → 181
    Mpv17_PMP22; Mpv17 / PMP22 family

  3. NM_001297852.1 → NP_001284781.1  uncharacterized protein Dmel_CG14777, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W588, Q9XZT2
    Conserved Domains (1) summary
    pfam04117
    Location:118 → 181
    Mpv17_PMP22; Mpv17 / PMP22 family

  4. NM_001297851.1 → NP_001284780.1  uncharacterized protein Dmel_CG14777, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284780.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W588, Q9XZT2
    Conserved Domains (1) summary
    pfam04117
    Location:118 → 181
    Mpv17_PMP22; Mpv17 / PMP22 family

  5. NM_001169163.1 → NP_001162634.1  uncharacterized protein Dmel_CG14777, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162634.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W588, Q9XZT2
    Conserved Domains (1) summary
    pfam04117
    Location:118 → 181
    Mpv17_PMP22; Mpv17 / PMP22 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W588 Q9W588
Q9XZT2 Q9XZT2

Gene LinkOut

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