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Accs 1-aminocyclopropane-1-carboxylate synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 311218, updated on 27-Nov-2024

Summary

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Official Symbol
Accsprovided by RGD
Official Full Name
1-aminocyclopropane-1-carboxylate synthaseprovided by RGD
Primary source
RGD:1309314
See related
EnsemblRapid:ENSRNOG00000042533 AllianceGenome:RGD:1309314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309314
Summary
Predicted to enable identical protein binding activity and transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 26.5), Liver (RPKM 24.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Accs in Genome Data Viewer
Location:
3q31
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (100261940..100276400, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79805254..79820830, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82742830..82757273, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ALX homeobox 4 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene uncharacterized LOC120101603 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase-like Neighboring gene ATP synthase membrane subunit c locus 1, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. Koch KA, et al. Gene, 2001 Jul 11. PMID 11470512
  2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-aminocyclopropane-1-carboxylate synthase-like protein 1
Names
1-aminocyclopropane-1-carboxylate synthase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267534.2 → NP_001254463.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8J8YIP6, A6HNJ5
    Related
    ENSRNOP00000012214.9, ENSRNOT00000012214.9
    Conserved Domains (1) summary
    PLN02450
    Location:35 → 475
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  2. NM_001433376.1 → NP_001420305.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8J8YIP6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    100261940..100276400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762028.4 → XP_008760250.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

    Conserved Domains (1) summary
    PLN02450
    Location:35 → 475
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  2. XM_006234577.4 → XP_006234639.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YIP6, A6HNJ5
    Conserved Domains (1) summary
    PLN02450
    Location:35 → 475
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  3. XM_006234580.5 → XP_006234642.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YIP6, A6HNJ5
    Conserved Domains (1) summary
    PLN02450
    Location:35 → 475
    PLN02450; 1-aminocyclopropane-1-carboxylate synthase

  4. XM_063283677.1 → XP_063139747.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

  5. XM_063283676.1 → XP_063139746.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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