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CG3795 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31128, updated on 9-Dec-2024

Summary

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Official Symbol
CG3795provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0025378
Locus tag
Dmel_CG3795
See related
AllianceGenome:FB:FBgn0025378
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH24985; Dmel\CG3795; EG:9D2.4; SP160
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human KLK10 (kallikrein related peptidase 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG3795 in Genome Data Viewer
Location:
2B7-2B7; 1-0.2 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1708806..1710182, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1602839..1604215, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene b6 Neighboring gene a6 Neighboring gene Sarcoglycan delta Neighboring gene prage Neighboring gene Adenosine deaminase acting on RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. From sequence to chromosome: the tip of the X chromosome of D. melanogaster. Benos PV, et al. Science, 2000 Mar 24. PMID 10731137
  2. Molecular characterization of the singed wings locus of Drosophila melanogaster. Schwartz YB, et al. BMC Genet, 2004 Jun 9. PMID 15189568, Free PMC Article
  3. Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies. Nakano S, et al. PLoS Genet, 2023 Jun. PMID 37319131, Free PMC Article
  4. Serine proteases and their homologs in the Drosophila melanogaster genome: an initial analysis of sequence conservation and phylogenetic relationships. Ross J, et al. Gene, 2003 Jan 30. PMID 12568721
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG3795-PA
CG3795-PB
NP_001284790.1
NP_569939.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1708806..1710182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297861.1 → NP_001284790.1  uncharacterized protein Dmel_CG3795, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76920, Q8MRL2
    Conserved Domains (2) summary
    smart00020
    Location:60 → 278
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60 → 281
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_130583.3 → NP_569939.2  uncharacterized protein Dmel_CG3795, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76920, Q8MRL2
    Related
    FBpp0070268
    Conserved Domains (2) summary
    smart00020
    Location:60 → 278
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:60 → 281
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76920 O76920
Q8MRL2 Q8MRL2

Gene LinkOut

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