Scgdelta Sarcoglycan delta [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Scgdeltaprovided by FlyBase
Official Full Name: Sarcoglycan deltaprovided by FlyBase
Primary source: FLYBASE:FBgn0025391
Locus tag: Dmel_CG14808
See related: AllianceGenome:FB:FBgn0025391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH21860; CG14808; CT34621; Dmel\CG14808; DmSCG-gammadelta; EG:4F1.1; GH21860; Sgcd
Summary: Predicted to be a structural constituent of muscle. Involved in heart contraction; mesoderm development; and sarcomere organization. Located in costamere. Is expressed in several structures, including gut section; head mesoderm; larval brain; larval central nervous system; and larval muscle system. Used to study cardiomyopathy; dilated cardiomyopathy 1L; and muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2C; autosomal recessive limb-girdle muscular dystrophy type 2F; dilated cardiomyopathy 1L; muscular dystrophy; and type 2 diabetes mellitus. Orthologous to human SGCD (sarcoglycan delta); SGCG (sarcoglycan gamma); and SGCZ (sarcoglycan zeta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1735945..1754065, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1629978..1648098, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of sarcoglycan complex	IEA Inferred from Electronic Annotation more info
part_of sarcoglycan complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG14808-PA; CG14808-PC; CG14808-PD; CG14808-PE; Scgdelta-PA; Scgdelta-PC; Scgdelta-PD; Scgdelta-PE; delta-sarcoglycan; sarcoglycan; sarcoglycan-like

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The following sections contain reference sequences that belong to a specific genome build. Explain