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Meis2 Meis homeobox 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311311, updated on 4-Jan-2025

Summary

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Official Symbol
Meis2provided by RGD
Official Full Name
Meis homeobox 2provided by RGD
Primary source
RGD:1305198
See related
EnsemblRapid:ENSRNOG00000004730 AllianceGenome:RGD:1305198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pancreas development; response to growth factor; and response to mechanical stimulus. Predicted to be located in nucleus. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 250.9), Uterus (RPKM 119.9) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Meis2 in Genome Data Viewer
Location:
3q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (123197066..123399002, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (102742904..102944833, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (107560172..107762732, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553090 Neighboring gene CDAN1 interacting nuclease 1 Neighboring gene uncharacterized LOC134486425 Neighboring gene uncharacterized LOC103691864 Neighboring gene uncharacterized LOC102555456

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. Gustafsson E, et al. Eur J Neurosci, 2003 Jun. PMID 12823474
  2. Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation. Peters K, et al. Virchows Arch, 2005 Jan. PMID 15660282
  3. Heterozygous loss-of-function variants of MEIS2 cause a triad of palatal defects, congenital heart defects, and intellectual disability. Verheije R, et al. Eur J Hum Genet, 2019 Feb. PMID 30291340, Free PMC Article
  4. Genome-wide association study identifies seven novel susceptibility loci for primary open-angle glaucoma. Shiga Y, et al. Hum Mol Genet, 2018 Apr 15. PMID 29452408, Free PMC Article
  5. Meis2 represses the osteoblastic transdifferentiation of aortic valve interstitial cells through the Notch1/Twist1 pathway. Sun C, et al. Biochem Biophys Res Commun, 2019 Feb 5. PMID 30594396

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in pancreas development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in positive regulation of cardiac muscle myoblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to growth factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
homeobox protein Meis2
Names
Meis1, myeloid ecotropic viral integration site 1 homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415696.1 → NP_001402625.1  homeobox protein Meis2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2JT27

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    123197066..123399002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234746.5 → XP_006234808.1  homeobox protein Meis2 isoform X2

    UniProtKB/TrEMBL
    A6HP86
    Conserved Domains (2) summary
    pfam05920
    Location:313 → 352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129 → 212
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_039104936.2 → XP_038960864.1  homeobox protein Meis2 isoform X1

    UniProtKB/TrEMBL
    A6HP86
    Conserved Domains (3) summary
    pfam05920
    Location:313 → 352
    Homeobox_KN; Homeobox KN domain
    pfam09770
    Location:354 → 482
    PAT1; Topoisomerase II-associated protein PAT1
    pfam16493
    Location:129 → 213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_006234749.5 → XP_006234811.1  homeobox protein Meis2 isoform X5

    UniProtKB/TrEMBL
    A6HP86
    Conserved Domains (2) summary
    pfam05920
    Location:294 → 333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110 → 193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. XM_006234747.5 → XP_006234809.1  homeobox protein Meis2 isoform X3

    UniProtKB/TrEMBL
    A6HP86
    Related
    ENSRNOP00000047254.6, ENSRNOT00000051638.6
    Conserved Domains (2) summary
    pfam05920
    Location:294 → 333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110 → 193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  5. XM_039104937.2 → XP_038960865.1  homeobox protein Meis2 isoform X6

    UniProtKB/TrEMBL
    A6HP86, D4A2T5
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109 → 193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. XM_006234748.5 → XP_006234810.1  homeobox protein Meis2 isoform X4

    UniProtKB/TrEMBL
    A6HP86
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109 → 192
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  7. XM_006234751.5 → XP_006234813.1  homeobox protein Meis2 isoform X8

    See identical proteins and their annotated locations for XP_006234813.1

    UniProtKB/TrEMBL
    A0A0G2JT27
    Conserved Domains (2) summary
    pfam05920
    Location:313 → 352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129 → 213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  8. XM_006234750.5 → XP_006234812.1  homeobox protein Meis2 isoform X7

    See identical proteins and their annotated locations for XP_006234812.1

    UniProtKB/TrEMBL
    A0A0G2JT27
    Conserved Domains (2) summary
    pfam05920
    Location:313 → 352
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:129 → 213
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  9. XM_006234752.5 → XP_006234814.1  homeobox protein Meis2 isoform X9

    See identical proteins and their annotated locations for XP_006234814.1

    UniProtKB/TrEMBL
    A0A0G2JT27
    Related
    ENSRNOP00000093627.2, ENSRNOT00000098248.2
    Conserved Domains (2) summary
    pfam05920
    Location:294 → 333
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:110 → 194
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  10. XM_006234755.5 → XP_006234817.1  homeobox protein Meis2 isoform X11

    See identical proteins and their annotated locations for XP_006234817.1

    UniProtKB/TrEMBL
    A0A0G2JT27
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109 → 193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  11. XM_006234753.5 → XP_006234815.1  homeobox protein Meis2 isoform X10

    See identical proteins and their annotated locations for XP_006234815.1

    UniProtKB/TrEMBL
    A0A0G2JT27, A0A8I6AHY1
    Related
    ENSRNOP00000068546.3, ENSRNOT00000077091.3
    Conserved Domains (2) summary
    pfam05920
    Location:293 → 332
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:109 → 193
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107758.2: Suppressed sequence

    Description
    NM_001107758.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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