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Frmd5 FERM domain containing 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311362, updated on 27-Nov-2024

Summary

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Official Symbol
Frmd5provided by RGD
Official Full Name
FERM domain containing 5provided by RGD
Primary source
RGD:1561554
See related
EnsemblRapid:ENSRNOG00000016189 AllianceGenome:RGD:1561554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561554
Summary
Predicted to enable integrin binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actomyosin structure organization; negative regulation of cell motility; and positive regulation of cell adhesion. Predicted to be located in adherens junction. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 238.1), Heart (RPKM 199.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Frmd5 in Genome Data Viewer
Location:
3q35
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128945812..129217134, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108492099..108763715, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113480780..113755286, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 1A Neighboring gene WD repeat domain 76 Neighboring gene uncharacterized LOC120101916 Neighboring gene ribosomal protein S4, X-linked, pseudogene 2 Neighboring gene barrier-to-autointegration factor-like Neighboring gene prohibitin 2, pseudogene 2 Neighboring gene golgi membrane protein 2 Neighboring gene uncharacterized LOC134486142 Neighboring gene CTD small phosphatase like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression. Wang T, et al. FEBS Lett, 2012 Sep 21. PMID 22846708
  2. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1. Hu J, et al. FEBS Lett, 2014 Nov 28. PMID 25448675
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FERM domain containing 5; FERM domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430431.1 → NP_001417360.1  FERM domain containing 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_001430432.1 → NP_001417361.1  FERM domain containing 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  3. NM_001430433.1 → NP_001417362.1  FERM domain containing 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    128945812..129217134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762214.4 → XP_008760436.2  FERM domain-containing protein 5 isoform X3

  2. XM_008762212.4 → XP_008760434.2  FERM domain-containing protein 5 isoform X11

    Related
    ENSRNOP00000094330.2, ENSRNOT00000105786.2

  3. XM_039106833.2 → XP_038962761.1  FERM domain-containing protein 5 isoform X6

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Conserved Domains (3) summary
    smart00295
    Location:19 → 210
    B41; Band 4.1 homologues
    pfam08736
    Location:338 → 383
    FA; FERM adjacent (FA)
    cl17171
    Location:191 → 324
    PH-like; Pleckstrin homology-like domain

  4. XM_039106834.2 → XP_038962762.1  FERM domain-containing protein 5 isoform X8

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Conserved Domains (3) summary
    smart00295
    Location:19 → 210
    B41; Band 4.1 homologues
    pfam08736
    Location:338 → 383
    FA; FERM adjacent (FA)
    cl17171
    Location:191 → 324
    PH-like; Pleckstrin homology-like domain

  5. XM_008762213.4 → XP_008760435.2  FERM domain-containing protein 5 isoform X12

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Related
    ENSRNOP00000081807.2, ENSRNOT00000111408.2

  6. XM_063284976.1 → XP_063141046.1  FERM domain-containing protein 5 isoform X9

    UniProtKB/TrEMBL
    A0A8I6B053
    Related
    ENSRNOP00000043316.6, ENSRNOT00000046659.7

  7. XM_039106827.2 → XP_038962755.1  FERM domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Conserved Domains (3) summary
    smart00295
    Location:19 → 210
    B41; Band 4.1 homologues
    pfam08736
    Location:333 → 378
    FA; FERM adjacent (FA)
    cl17171
    Location:191 → 319
    PH-like; Pleckstrin homology-like domain

  8. XM_039106826.2 → XP_038962754.1  FERM domain-containing protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Related
    ENSRNOP00000102428.1, ENSRNOT00000171719.1
    Conserved Domains (3) summary
    smart00295
    Location:19 → 210
    B41; Band 4.1 homologues
    pfam08736
    Location:338 → 383
    FA; FERM adjacent (FA)
    cl17171
    Location:191 → 324
    PH-like; Pleckstrin homology-like domain

  9. XM_008762211.4 → XP_008760433.2  FERM domain-containing protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Related
    ENSRNOP00000109013.1, ENSRNOT00000124753.1

  10. XM_063284978.1 → XP_063141048.1  FERM domain-containing protein 5 isoform X10

  11. XM_039106829.2 → XP_038962757.1  FERM domain-containing protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G8G4
    Conserved Domains (3) summary
    smart00295
    Location:4 → 177
    B41; Band 4.1 homologues
    pfam08736
    Location:305 → 350
    FA; FERM adjacent (FA)
    cl17171
    Location:158 → 291
    PH-like; Pleckstrin homology-like domain

  12. XM_063284975.1 → XP_063141045.1  FERM domain-containing protein 5 isoform X7

  13. XM_063284977.1 → XP_063141047.1  FERM domain-containing protein 5 isoform X10

  14. XM_063284979.1 → XP_063141049.1  FERM domain-containing protein 5 isoform X13

  15. XM_039106836.2 → XP_038962764.1  FERM domain-containing protein 5 isoform X14

    Conserved Domains (2) summary
    pfam08736
    Location:116 → 161
    FA; FERM adjacent (FA)
    cl17171
    Location:50 → 102
    PH-like; Pleckstrin homology-like domain

  16. XM_063284980.1 → XP_063141050.1  FERM domain-containing protein 5 isoform X15

  17. XM_039106837.2 → XP_038962765.1  FERM domain-containing protein 5 isoform X14

    Conserved Domains (2) summary
    pfam08736
    Location:116 → 161
    FA; FERM adjacent (FA)
    cl17171
    Location:50 → 102
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_010064879.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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