U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gcna Germ cell nuclear acidic peptidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31139, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Gcnaprovided by FlyBase
Official Full Name
Germ cell nuclear acidic peptidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0023515
Locus tag
Dmel_CG14814
See related
AllianceGenome:FB:FBgn0023515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14814; Dmel\CG14814; EG:63B12.6
Summary
Enables DNA topoisomerase binding activity and MCM complex binding activity. Involved in positive regulation of DNA repair and protein-DNA covalent cross-linking repair. Located in P granule and chromosome. Is expressed in several structures, including CNS glial cell; germline cell; head mesoderm; somatic muscle primordium; and trunk mesoderm. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 4. Orthologous to human GCNA (germ cell nuclear acidic peptidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gcna in Genome Data Viewer
Location:
2B13-2B13; 1-0.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1862009..1865835, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1756042..1759868, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene Coat Protein (coatomer) delta Neighboring gene Mediator complex subunit 18 Neighboring gene Peroxin 5 Neighboring gene uncharacterized protein Neighboring gene Phosphoglycerate mutase 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recurrent Duplication and Diversification of a Vital DNA Repair Gene Family Across Drosophila. Brand CL, et al. Mol Biol Evol, 2024 Jun 1. PMID 38865490, Free PMC Article
  2. GCNA Preserves Genome Integrity and Fertility Across Species. Bhargava V, et al. Dev Cell, 2020 Jan 6. PMID 31839537, Free PMC Article
  3. The Drosophila MSL complex activates the transcription of target genes. Straub T, et al. Genes Dev, 2005 Oct 1. PMID 16204179, Free PMC Article
  4. Systematic imaging reveals features and changing localization of mRNAs in Drosophila development. Jambor H, et al. Elife, 2015 Apr 2. PMID 25838129, Free PMC Article
  5. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA topoisomerase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables MCM complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-DNA covalent cross-linking repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
germ cell nuclear acidic peptidase
Names
CG14814-PA
CG14814-PB
CG14814-PD
Gcna-PA
Gcna-PB
Gcna-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1862009..1865835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297864.1 → NP_001284793.1  germ cell nuclear acidic peptidase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284793.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KW09
    UniProtKB/TrEMBL
    Q8MZ30
    Conserved Domains (1) summary
    smart00731
    Location:799 → 951
    SprT; SprT homologues

  2. NM_166909.3 → NP_726770.2  germ cell nuclear acidic peptidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726770.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KW09
    UniProtKB/TrEMBL
    Q8MZ30
    Related
    FBpp0070354
    Conserved Domains (1) summary
    smart00731
    Location:799 → 951
    SprT; SprT homologues

  3. NM_130591.3 → NP_569947.2  germ cell nuclear acidic peptidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569947.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8WHE2, O46086, Q9W554
    Related
    FBpp0070353
    Conserved Domains (1) summary
    smart00731
    Location:821 → 973
    SprT; SprT homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K7T1 Q7K7T1
Q7KW09.1 Q7KW09
Q8MZ30 Q8MZ30
Q8T9J2 Q8T9J2
Q9W554 Q9W554

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools