Vps26 Vacuolar protein sorting 26 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vps26provided by FlyBase
Official Full Name: Vacuolar protein sorting 26provided by FlyBase
Primary source: FLYBASE:FBgn0014411
Locus tag: Dmel_CG14804
See related: AllianceGenome:FB:FBgn0014411
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 131F2S; anon-sts13; CG14804; Dmel\CG14804; DmVps26; dvps26; dVps26; Dvps26; EG:63B12.8; ESTS:131F2S; vps26; VPS26
Summary: Enables cargo receptor activity. Involved in endosome to plasma membrane protein transport and regulation of Wnt signaling pathway. Part of retromer complex. Is expressed in adult head; adult heart; and photoreceptor neurons. Used to study brain cancer. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to several human genes including VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1873853..1876474)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1767886..1770507)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cargo receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endosome to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer, cargo-selective complex	ISS Inferred from Sequence or Structural Similarity more info

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The following sections contain reference sequences that belong to a specific genome build. Explain