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Kif16b kinesin family member 16B [ Rattus norvegicus (Norway rat) ]

Gene ID: 311478, updated on 27-Nov-2024

Summary

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Official Symbol
Kif16bprovided by RGD
Official Full Name
kinesin family member 16Bprovided by RGD
Primary source
RGD:1310146
See related
EnsemblRapid:ENSRNOG00000004951 AllianceGenome:RGD:1310146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including ATP hydrolysis activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi to endosome transport; cell surface receptor protein tyrosine kinase signaling pathway; and early endosome to late endosome transport. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in early endosome; phagocytic vesicle; and spindle. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 118.4), Lung (RPKM 71.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kif16b in Genome Data Viewer
Location:
3q41
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (150428233..150707755, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (129974692..130254194, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (136596621..136936809, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554505 Neighboring gene uncharacterized LOC120101717 Neighboring gene uncharacterized LOC120101718 Neighboring gene uncharacterized LOC134486454 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nuclear ribonucleoprotein polypeptide B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Hoepfner S, et al. Cell, 2005 May 6. PMID 15882625
  2. The structural basis of novel endosome anchoring activity of KIF16B kinesin. Blatner NR, et al. EMBO J, 2007 Aug 8. PMID 17641687, Free PMC Article
  3. KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor. Ueno H, et al. Dev Cell, 2011 Jan 18. PMID 21238925
  4. The phagosomal proteome in interferon-gamma-activated macrophages. Trost M, et al. Immunity, 2009 Jan 16. PMID 19144319
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoderm development ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of primary germ layer ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107783.2 → NP_001101253.2  kinesin-like protein KIF16B

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6K727
    Related
    ENSRNOP00000111013.1, ENSRNOT00000137987.1
    Conserved Domains (5) summary
    cd06874
    Location:1178 → 1305
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    150428233..150707755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283800.1 → XP_063139870.1  kinesin-like protein KIF16B isoform X10

    UniProtKB/TrEMBL
    D3ZFN9
    Related
    ENSRNOP00000031372.5, ENSRNOT00000036273.6

  2. XM_039105043.2 → XP_038960971.1  kinesin-like protein KIF16B isoform X9

    UniProtKB/TrEMBL
    A6K727
    Conserved Domains (6) summary
    cd06874
    Location:1192 → 1319
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    TIGR02168
    Location:833 → 1086
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:15 → 368
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam17380
    Location:614 → 889
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:481 → 546
    FHA; FHA domain
    pfam16183
    Location:367 → 479
    Kinesin_assoc; Kinesin-associated

  3. XM_039105044.2 → XP_038960972.1  kinesin-like protein KIF16B isoform X11

    UniProtKB/TrEMBL
    A6K727
    Conserved Domains (6) summary
    cd06874
    Location:1181 → 1308
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    COG1196
    Location:605 → 941
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:822 → 1075
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:15 → 368
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:481 → 546
    FHA; FHA domain
    pfam16183
    Location:367 → 479
    Kinesin_assoc; Kinesin-associated

  4. XM_006235113.5 → XP_006235175.2  kinesin-like protein KIF16B isoform X12

    UniProtKB/TrEMBL
    A6K727
    Related
    ENSRNOP00000082939.2, ENSRNOT00000118037.2
    Conserved Domains (6) summary
    TIGR02168
    Location:833 → 1086
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:15 → 368
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam17380
    Location:614 → 889
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:481 → 546
    FHA; FHA domain
    pfam16183
    Location:367 → 479
    Kinesin_assoc; Kinesin-associated
    cl02563
    Location:1192 → 1274
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  5. XM_063283799.1 → XP_063139869.1  kinesin-like protein KIF16B isoform X8

  6. XM_039105041.2 → XP_038960969.1  kinesin-like protein KIF16B isoform X6

    Conserved Domains (5) summary
    TIGR00618
    Location:581 → 1149
    sbcc; exonuclease SbcC
    pfam17380
    Location:579 → 859
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:451 → 516
    FHA; FHA domain
    pfam16183
    Location:337 → 449
    Kinesin_assoc; Kinesin-associated
    cl22853
    Location:1 → 338
    Motor_domain; Myosin and Kinesin motor domain

  7. XM_008762263.4 → XP_008760485.1  kinesin-like protein KIF16B isoform X5

    Conserved Domains (7) summary
    cd01365
    Location:5 → 353
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00225
    Location:1 → 346
    Kinesin; Kinesin motor domain
    pfam00498
    Location:466 → 531
    FHA; FHA domain
    pfam00769
    Location:750 → 870
    ERM; Ezrin/radixin/moesin family
    pfam12474
    Location:595 → 753
    PKK; Polo kinase kinase
    pfam16183
    Location:352 → 464
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:599 → 669
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  8. XM_063283798.1 → XP_063139868.1  kinesin-like protein KIF16B isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZVW2

  9. XM_006235108.5 → XP_006235170.1  kinesin-like protein KIF16B isoform X2

    Conserved Domains (7) summary
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam00769
    Location:762 → 882
    ERM; Ezrin/radixin/moesin family
    pfam12474
    Location:607 → 765
    PKK; Polo kinase kinase
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:611 → 681
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  10. XM_039105042.2 → XP_038960970.1  kinesin-like protein KIF16B isoform X7

    Conserved Domains (5) summary
    TIGR00618
    Location:572 → 1140
    sbcc; exonuclease SbcC
    pfam17380
    Location:570 → 850
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:442 → 507
    FHA; FHA domain
    pfam16183
    Location:328 → 440
    Kinesin_assoc; Kinesin-associated
    cl22853
    Location:15 → 329
    Motor_domain; Myosin and Kinesin motor domain

  11. XM_039105039.2 → XP_038960967.1  kinesin-like protein KIF16B isoform X1

    Conserved Domains (5) summary
    TIGR00618
    Location:611 → 1179
    sbcc; exonuclease SbcC
    cd01365
    Location:15 → 368
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam17380
    Location:609 → 889
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:481 → 546
    FHA; FHA domain
    pfam16183
    Location:367 → 479
    Kinesin_assoc; Kinesin-associated

  12. XM_039105040.2 → XP_038960968.1  kinesin-like protein KIF16B isoform X3

    Conserved Domains (5) summary
    COG1196
    Location:605 → 941
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:822 → 1075
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd01365
    Location:15 → 368
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:481 → 546
    FHA; FHA domain
    pfam16183
    Location:367 → 479
    Kinesin_assoc; Kinesin-associated

  13. XM_008762265.4 → XP_008760487.1  kinesin-like protein KIF16B isoform X6

    See identical proteins and their annotated locations for XP_008760487.1

    Conserved Domains (5) summary
    TIGR00618
    Location:581 → 1149
    sbcc; exonuclease SbcC
    pfam17380
    Location:579 → 859
    DUF5401; Family of unknown function (DUF5401)
    pfam00498
    Location:451 → 516
    FHA; FHA domain
    pfam16183
    Location:337 → 449
    Kinesin_assoc; Kinesin-associated
    cl22853
    Location:1 → 338
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_005501888.2 RNA Sequence

    Related
    ENSRNOT00000162887.1
Nucleotide Protein Strain
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