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mip130 Myb-interacting protein 130 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31153, updated on 4-Jan-2025

Summary

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Official Symbol
mip130provided by FlyBase
Official Full Name
Myb-interacting protein 130provided by FlyBase
Primary source
FLYBASE:FBgn0023509
Locus tag
Dmel_CG3480
See related
AllianceGenome:FB:FBgn0023509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
86E4.4; CG3480; Dmel\CG3480; EG:86E4.4; Mip130; Mip130/TWIT; Mip130/Twt; twit; Twit; TWIT
Summary
Enables DNA binding activity. Involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of DRM complex and Myb complex. Is active in nucleus. Is expressed in adult brain cell body rind; adult head; and organism. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See mip130 in Genome Data Viewer
Location:
2B15-2B16; 1-0.2 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1908239..1920318)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1802272..1814351)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45929 Neighboring gene antisense RNA:CR43864 Neighboring gene Lipid droplet assembly factor 1 Neighboring gene uncharacterized protein Neighboring gene ER degradation enhancer, mannosidase alpha-like 1 Neighboring gene Rabconnectin-3B Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon Neighboring gene Oculocerebrorenal syndrome of Lowe Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Beall EL, et al. Genes Dev, 2004 Jul 15. PMID 15256498, Free PMC Article
  2. The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin. Rovani MK, et al. Dev Biol, 2012 Dec 1. PMID 22960039, Free PMC Article
  3. A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Vorster PJ, et al. Biol Open, 2020 May 7. PMID 32295830, Free PMC Article
  4. Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Andrejka L, et al. Proc Natl Acad Sci U S A, 2011 Oct 18. PMID 21969598, Free PMC Article
  5. Epigenetic regulation of olfactory receptor gene expression by the Myb-MuvB/dREAM complex. Sim CK, et al. Genes Dev, 2012 Nov 15. PMID 23105004, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that L(3)mbt chromosomal targeting requires proteins of a site-specific DNA binding complex Myb-MuvB (MMB core component Mip130)/DREAM.
    Title: Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.
  2. Cell cycle specific degradation of Mip130 is likely to be utilized as a key regulatory mechanism in down-regulating the activity of the Myb complex.
    Title: Two components of the Myb complex, DMyb and Mip130, are specifically associated with euchromatin and degraded during prometaphase throughout development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eggshell chorion gene amplification IC
Inferred by Curator
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reproductive process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DRM complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Myb complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Myb-interacting protein 130
Names
CG3480-PA
mip130-PA
twilight

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1908239..1920318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130602.4 → NP_569958.2  Myb-interacting protein 130 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569958.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46093, Q9W542
    Related
    FBpp0070302
    Conserved Domains (1) summary
    pfam06584
    Location:311 → 419
    DIRP; DIRP
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46093 O46093
Q9W542 Q9W542

Gene LinkOut

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