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Edem1 ER degradation enhancer, mannosidase alpha-like 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31154, updated on 4-Jan-2025

Summary

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Official Symbol
Edem1provided by FlyBase
Official Full Name
ER degradation enhancer, mannosidase alpha-like 1provided by FlyBase
Primary source
FLYBASE:FBgn0023511
Locus tag
Dmel_CG3810
See related
AllianceGenome:FB:FBgn0023511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1; EDEM1; EG.86E4.2; EG:86E4.2
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in determination of adult lifespan; endoplasmic reticulum unfolded protein response; and ubiquitin-dependent glycoprotein ERAD pathway. Located in endoplasmic reticulum. Is expressed in gonad; imaginal disc; larval central nervous system; ring gland; and spermatozoon. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Edem1 in Genome Data Viewer
Location:
2B15-2B15; 1-0.2 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1903704..1908827, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1797737..1802860, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45929 Neighboring gene antisense RNA:CR43864 Neighboring gene Lipid droplet assembly factor 1 Neighboring gene uncharacterized protein Neighboring gene Myb-interacting protein 130 Neighboring gene Rabconnectin-3B Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of Drosophila EDEMs in the degradation of the alpha-1-antitrypsin Z variant. Jang BY, et al. Int J Mol Med, 2015 Apr. PMID 25716426, Free PMC Article
  2. The alpha-mannosidases: phylogeny and adaptive diversification. Gonzalez DS, et al. Mol Biol Evol, 2000 Feb. PMID 10677852
  3. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Marcora MS, et al. Neurobiol Aging, 2017 Dec. PMID 28917667
  4. Participation of dengue virus NS4B protein in the modulation of immune effectors dependent on ER stress in insect cells. Sepúlveda-Salinas KJ, et al. Cell Stress Chaperones, 2017 Nov. PMID 28755304, Free PMC Article
  5. Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Liu YL, et al. Aging Cell, 2009 Aug. PMID 19302370, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
    Title: Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum mannose trimming IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent glycoprotein ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER degradation enhancer, mannosidase alpha-like 1
Names
CG3810-PA
CG3810-PB
CG3810-PC
CG3810-PD
CG3810-PE
Edem1-PA
Edem1-PB
Edem1-PC
Edem1-PD
Edem1-PE
NP_001245483.1
NP_001259152.1
NP_569959.1
NP_726777.1
NP_726778.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1903704..1908827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166915.2 → NP_726778.1  ER degradation enhancer, mannosidase alpha-like 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46091, Q7JUF8
    Related
    FBpp0070337
    Conserved Domains (1) summary
    pfam01532
    Location:48 → 486
    Glyco_hydro_47; Glycosyl hydrolase family 47

  2. NM_001272223.2 → NP_001259152.1  ER degradation enhancer, mannosidase alpha-like 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259152.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PG98, O46091
    Conserved Domains (1) summary
    pfam01532
    Location:48 → 486
    Glyco_hydro_47; Glycosyl hydrolase family 47

  3. NM_001258554.2 → NP_001245483.1  ER degradation enhancer, mannosidase alpha-like 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46091, Q7JUF8
    Conserved Domains (1) summary
    pfam01532
    Location:48 → 486
    Glyco_hydro_47; Glycosyl hydrolase family 47

  4. NM_130603.3 → NP_569959.1  ER degradation enhancer, mannosidase alpha-like 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569959.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46091, Q7JUF8
    Related
    FBpp0070338
    Conserved Domains (1) summary
    pfam01532
    Location:48 → 486
    Glyco_hydro_47; Glycosyl hydrolase family 47

  5. NM_166914.2 → NP_726777.1  ER degradation enhancer, mannosidase alpha-like 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726777.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46091, Q7JUF8
    Related
    FBpp0070339
    Conserved Domains (1) summary
    pfam01532
    Location:48 → 486
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG98 M9PG98
O46091 O46091
Q7JUF8 Q7JUF8

Gene LinkOut

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