U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG4045 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31176, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
CG4045provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0025629
Locus tag
Dmel_CG4045
See related
AllianceGenome:FB:FBgn0025629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG4045; EG:22E5.4; METTL1
Summary
Predicted to enable tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in RNA (guanine-N7)-methylation and tRNA methylation. Predicted to be located in nucleus. Predicted to be part of tRNA (m7G46) methyltransferase complex. Is expressed in anterior midgut primordium; embryonic/larval midgut; organism; posterior midgut primordium; and tracheal primordium. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG4045 in Genome Data Viewer
Location:
2C10-2C10; 1-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2074795..2075900, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1968828..1969933, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44382 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 76

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mettl1-dependent m(7)G tRNA modification is essential for maintaining spermatogenesis and fertility in Drosophila melanogaster. Kaneko S, et al. Nat Commun, 2024 Sep 24. PMID 39317727, Free PMC Article
  2. Regulation of axon regeneration by the RNA repair and splicing pathway. Song Y, et al. Nat Neurosci, 2015 Jun. PMID 25961792, Free PMC Article
  3. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article
  4. Characterization of gene expression regulated by human OTK18 using Drosophila melanogaster as a model system for innate immunity. Spresser CR, et al. J Genet, 2008 Aug. PMID 18776638
  5. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (guanine(46)-N7)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanine(46)-N7)-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in RNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA (guanine-N7)-methylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of tRNA (m7G46) methyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of tRNA methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG4045-PA
NP_569978.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2074795..2075900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130622.3 → NP_569978.1  uncharacterized protein Dmel_CG4045 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569978.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O77263, Q9W527
    Related
    FBpp0070317
    Conserved Domains (1) summary
    pfam02390
    Location:71 → 251
    Methyltransf_4; Putative methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77263.1 O77263

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools