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CG4025 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31177, updated on 4-Jan-2025

Summary

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Official Symbol
CG4025provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0025624
Locus tag
Dmel_CG4025
See related
AllianceGenome:FB:FBgn0025624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.169; Dmel\CG4025; DRAM; EG:22E5.9
Summary
Predicted to be involved in regulation of autophagy. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in acute myocardial infarction and cone-rod dystrophy 21. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1) and DRAM2 (DNA damage regulated autophagy modulator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG4025 in Genome Data Viewer
Location:
2C10-2C10; 1-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2076966..2078455)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1970999..1972488)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44382 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 76 Neighboring gene corkscrew

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. O'Prey J, et al. Cell Cycle, 2009 Jul 15. PMID 19556885
  2. Genetic dissection of the phosphoinositide cycle in Drosophila photoreceptors. Liu CH, et al. J Cell Sci, 2018 Apr 19. PMID 29567856, Free PMC Article
  3. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
  4. Temporal Exposure to Bt Insecticide Causes Oxidative Stress in Larval Midgut Tissue. Muita BK, et al. Toxins (Basel), 2023 May 7. PMID 37235357, Free PMC Article
  5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG4025-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2076966..2078455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130623.3 → NP_569979.1  uncharacterized protein Dmel_CG4025 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O77262
    Related
    FBpp0070359
    Conserved Domains (1) summary
    pfam10277
    Location:5 → 229
    Frag1; Frag1/DRAM/Sfk1 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O77262 O77262

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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