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Unc-76 Uncoordinated 76 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31179, updated on 9-Dec-2024

Summary

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Official Symbol
Unc-76provided by FlyBase
Official Full Name
Uncoordinated 76provided by FlyBase
Primary source
FLYBASE:FBgn0040395
Locus tag
Dmel_CG3981
See related
AllianceGenome:FB:FBgn0040395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH10260; CG18851; CG3981; Dmel\CG3981; Dunc-76; EG:67A9.1; l(1)G0066; l(1)G0158; l(1)G0310; l(1)G0333; l(1)G0360; unc-76; UNC-76; unc76
Summary
Enables kinesin binding activity. Involved in axo-dendritic transport. Predicted to be active in axon and cytoplasm. Is expressed in larval longitudinal connective; larval segmental nerve; larval ventral nerve cord commissure; and presumptive embryonic/larval central nervous system. Used to study Jacobsen Syndrome. Orthologous to several human genes including FEZ1 (fasciculation and elongation protein zeta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Unc-76 in Genome Data Viewer
Location:
2C10-2D1; 1-0.6 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2080610..2093948)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1974643..1987981)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene corkscrew Neighboring gene polyhomeotic distal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes. Hakeemi MS, et al. BMC Biol, 2022 Feb 8. PMID 35135533, Free PMC Article
  2. Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development. Gunaseelan S, et al. Hum Mol Genet, 2021 Mar 25. PMID 33395696
  3. The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system. Gindhart JG, et al. Mol Biol Cell, 2003 Aug. PMID 12925768, Free PMC Article
  4. Role of kinesin-1-based microtubule sliding in Drosophila nervous system development. Winding M, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27512046, Free PMC Article
  5. A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones. Siebert M, et al. Elife, 2015 Aug 14. PMID 26274777, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
    Title: Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
  2. UNC-76 is required for kinesin-dependent axonal transport
    Title: The kinesin-associated protein UNC-76 is required for axonal transport in the Drosophila nervous system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables kinesin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncoordinated 76
Names
CG3981-PA
CG3981-PB
CG3981-PC
CG3981-PD
Unc-76-PA
Unc-76-PB
Unc-76-PC
Unc-76-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2080610..2093948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272243.1 → NP_001259172.1  uncoordinated 76, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0E2, Q9TVM9, Q9W525
    Conserved Domains (1) summary
    pfam07763
    Location:143 → 418
    FEZ; FEZ-like protein

  2. NM_130625.3 → NP_569981.1  uncoordinated 76, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569981.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0E2, Q9TVM9, Q9W525
    Related
    FBpp0070360
    Conserved Domains (1) summary
    pfam07763
    Location:143 → 418
    FEZ; FEZ-like protein

  3. NM_166927.2 → NP_726792.1  uncoordinated 76, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0E2, Q9TVM9, Q9W525
    Related
    FBpp0070361
    Conserved Domains (1) summary
    pfam07763
    Location:143 → 418
    FEZ; FEZ-like protein

  4. NM_001272244.1 → NP_001259173.1  uncoordinated 76, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259173.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGS9
    Conserved Domains (1) summary
    pfam07763
    Location:1 → 233
    FEZ; FEZ-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGS9 M9PGS9
Q8T0S7 Q8T0S7
Q9TVM9 Q9TVM9
Q9W525 Q9W525

Gene LinkOut

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