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Adamtsl2 ADAMTS-like 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311827, updated on 4-Jan-2025

Summary

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Official Symbol
Adamtsl2provided by RGD
Official Full Name
ADAMTS-like 2provided by RGD
Primary source
RGD:1305459
See related
EnsemblRapid:ENSRNOG00000027742 AllianceGenome:RGD:1305459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305459
Summary
Predicted to enable microfibril binding activity. Predicted to act upstream of or within extracellular matrix organization; lobar bronchus epithelium development; and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in geleophysic dysplasia 1. Orthologous to human ADAMTSL2 (ADAMTS like 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 177.3), Kidney (RPKM 76.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Adamtsl2 in Genome Data Viewer
Location:
3p12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (30795882..30832635)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (10397774..10434557)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (5624473..5654890)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene calcium channel flower domain containing 1 Neighboring gene solute carrier family 2 member 6 Neighboring gene myomaker, myoblast fusion factor Neighboring gene family with sequence similarity 163, member B Neighboring gene uncharacterized LOC134486349

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts. Rypdal KB, et al. Sci Rep, 2021 Oct 5. PMID 34611183, Free PMC Article
  2. ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. Le Goff C, et al. Nat Genet, 2008 Sep. PMID 18677313, Free PMC Article
  3. ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. Koo BH, et al. Matrix Biol, 2007 Jul. PMID 17509843
  4. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia. Hubmacher D, et al. Dis Model Mech, 2015 May. PMID 25762570, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFbeta signalling in cardiac fibroblasts.
    Title: The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfibril binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lobar bronchus epithelium development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADAMTS-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427090.1 → NP_001414019.1  ADAMTS-like protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JTK4, D4A4X6
    Related
    ENSRNOP00000030753.5, ENSRNOT00000036995.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    30795882..30832635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106142.2 → XP_038962070.1  ADAMTS-like protein 2 isoform X1

    UniProtKB/TrEMBL
    A6JTK4, D4A4X6
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:922 → 953
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:804 → 860
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_039106144.2 → XP_038962072.1  ADAMTS-like protein 2 isoform X5

    Conserved Domains (3) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:574 → 628
    TSP1_ADAMTS; Thrombospondin type 1 domain

  3. XM_063283923.1 → XP_063139993.1  ADAMTS-like protein 2 isoform X3

  4. XM_039106143.2 → XP_038962071.1  ADAMTS-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JTK4
    Conserved Domains (4) summary
    smart00209
    Location:50 → 106
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:216 → 330
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:888 → 919
    PLAC; PLAC (protease and lacunin) domain
    pfam19030
    Location:770 → 826
    TSP1_ADAMTS; Thrombospondin type 1 domain

  5. XM_063283924.1 → XP_063139994.1  ADAMTS-like protein 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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