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Sh3glb2 SH3 domain-containing GRB2-like endophilin B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311848, updated on 4-Jan-2025

Summary

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Official Symbol
Sh3glb2provided by RGD
Official Full Name
SH3 domain-containing GRB2-like endophilin B2provided by RGD
Primary source
RGD:1305886
See related
EnsemblRapid:ENSRNOG00000017295 AllianceGenome:RGD:1305886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 436.1), Adrenal (RPKM 142.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3glb2 in Genome Data Viewer
Location:
3p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34014746..34029607, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13616936..13631785, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8909231..8924066, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase Neighboring gene mitoguardin 2 Neighboring gene ribosomal protein L38 like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Loebrich S, et al. Curr Biol, 2016 Feb 8. PMID 26776730
  2. SH3GLB, a new endophilin-related protein family featuring an SH3 domain. Pierrat B, et al. Genomics, 2001 Jan 15. PMID 11161816
  3. Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch. Desrochers G, et al. J Biol Chem, 2017 Apr 14. PMID 28235806, Free PMC Article
  4. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859, Free PMC Article
  5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105723

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic endocytic zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endophilin-B2
Names
SH3 domain-containing GRB2-like protein B2
SH3-containing protein SH3GLB2
SH3-domain GRB2-like endophilin B2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393780.1 → NP_001380709.1  endophilin-B2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K9P4
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cl17036
    Location:335 → 361
    SH3; Src Homology 3 domain superfamily

  2. NM_001393781.1 → NP_001380710.1  endophilin-B2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A0G2K9P4, A6JTX4
    Related
    ENSRNOP00000077030.2, ENSRNOT00000103772.2
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:339 → 393
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

RNA

  1. NR_172010.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    34014746..34029607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761662.4 → XP_008759884.1  endophilin-B2 isoform X5

    See identical proteins and their annotated locations for XP_008759884.1

    UniProtKB/TrEMBL
    A0A8I6GHN4, A6JTX1, A6JTX3
    Conserved Domains (2) summary
    cd07617
    Location:21 → 257
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:318 → 372
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  2. XM_006233822.5 → XP_006233884.1  endophilin-B2 isoform X4

    UniProtKB/TrEMBL
    A6JTX1
    Related
    ENSRNOP00000089795.2, ENSRNOT00000107109.2
    Conserved Domains (2) summary
    cd07617
    Location:21 → 257
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:323 → 377
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  3. XM_006233819.5 → XP_006233881.1  endophilin-B2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K9P4
    Conserved Domains (2) summary
    cd07617
    Location:21 → 278
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
    cd11944
    Location:344 → 398
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

  4. XM_063283947.1 → XP_063140017.1  endophilin-B2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GM93
    Related
    ENSRNOP00000084372.2, ENSRNOT00000116758.2

  5. XM_008761661.4 → XP_008759883.1  endophilin-B2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ43, A0A8I6GM93
    Related
    ENSRNOP00000085000.2, ENSRNOT00000100859.2
    Conserved Domains (2) summary
    cd11944
    Location:394 → 448
    SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
    cl12013
    Location:21 → 328
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_063283948.1 → XP_063140018.1  endophilin-B2 isoform X6

    UniProtKB/TrEMBL
    A6JTX6

  7. XM_039105239.2 → XP_038961167.1  endophilin-B2 isoform X8

    Conserved Domains (1) summary
    cd07617
    Location:21 → 257
    BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

  8. XM_063283949.1 → XP_063140019.1  endophilin-B2 isoform X7

  9. XM_063283950.1 → XP_063140020.1  endophilin-B2 isoform X9

    UniProtKB/TrEMBL
    A6JTX9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5PPJ9.2 GenPept UniProtKB/Swiss-Prot:Q5PPJ9

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials