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wapl wings apart-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31187, updated on 9-Dec-2024

Summary

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Official Symbol
waplprovided by FlyBase
Official Full Name
wings apart-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0004655
Locus tag
Dmel_CG3707
See related
AllianceGenome:FB:FBgn0004655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C204; CG3707; Dmel\CG3707; EG:87B1.2; l(1)2Dd; l(1)2Df; l(1)C204; l(1)N2; l(1)N5[72]; l74; N2; pasc; RNA D; RNAD; wap; Wapl; WAPL
Summary
Enables cohesin unloader activity. Involved in chromatin organization and sister chromatid cohesion. Located in chromatin and nucleus. Orthologous to human WAPL (WAPL cohesin release factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See wapl in Genome Data Viewer
Location:
2D4-2D5; 1-0.6 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2149936..2158983, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2043969..2053016, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene D-2-hydroxyglutaric acid dehydrogenase Neighboring gene Phosphogluconate dehydrogenase Neighboring gene bcn92 Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Controlling the false-positive rate in multilocus genome scans for selection. Thornton KR, et al. Genetics, 2007 Feb. PMID 17110489, Free PMC Article
  2. [Trans-effect of modifiers on position-effect variegation in a set of euchromatin-heterochromatin rearrangements in Drosophila melanogaster]. Popkova AM, et al. Genetika, 2001 Oct. PMID 11761621
  3. Inferring selection in partially sequenced regions. Jensen JD, et al. Mol Biol Evol, 2008 Feb. PMID 18165259
  4. The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster. Tolchkov EV, et al. Genetics, 2000 Apr. PMID 10747057, Free PMC Article
  5. Molecular characterization of the breakpoints of an inversion fixed between Drosophila melanogaster and D. subobscura. Cirera S, et al. Genetics, 1995 Jan. PMID 7705632, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings suggests that the mutant Wapl-AG might exert its effects through changes in cohesin binding; Wapl-AG was found to increase the stability of cohesin binding to polytene chromosomes
    Title: Wapl antagonizes cohesin binding and promotes Polycomb-group silencing in Drosophila.
  2. Study shows that DNA replication and cohesin acetylation promote binding of Sororin to cohesin, and that Sororin displaces Wapl from its binding partner Pds5; in the absence of Wapl, Sororin becomes dispensable for cohesion.
    Title: Sororin mediates sister chromatid cohesion by antagonizing Wapl.
  3. Nipped-B, Pds5, and the Wapl protein that interacts with Pds5 all play unique roles in cohesin chromosome binding.
    Title: Dosage-sensitive regulation of cohesin chromosome binding and dynamics by Nipped-B, Pds5, and Wapl.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cohesin unloader activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
wings apart-like
Names
CG3707-PA
CG3707-PB
CG3707-PC
parallel sister chromatids protein
wapl-PA
wapl-PB
wapl-PC
wings-apart-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2149936..2158983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297875.1 → NP_001284804.1  wings apart-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284804.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46095, Q24153, Q7KVZ8, Q8MRI2, Q9W517, Q9W518
    UniProtKB/TrEMBL
    A0A0F6QCC2, X2JAA8
    Conserved Domains (1) summary
    pfam07814
    Location:1152 → 1515
    WAPL; Wings apart-like protein regulation of heterochromatin

  2. NM_080303.3 → NP_525042.2  wings apart-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525042.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46095, Q24153, Q7KVZ8, Q8MRI2, Q9W517, Q9W518
    UniProtKB/TrEMBL
    A0A0F6QCC2, X2JAA8
    Related
    FBpp0070413
    Conserved Domains (1) summary
    pfam07814
    Location:1152 → 1515
    WAPL; Wings apart-like protein regulation of heterochromatin

  3. NM_166931.2 → NP_726796.2  wings apart-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726796.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0F6QB41, A0A0F6QB50
    Related
    FBpp0070414
    Conserved Domains (1) summary
    pfam07814
    Location:503 → 866
    WAPL; Wings apart-like protein regulation of heterochromatin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W517.1 Q9W517
X2JAA8 X2JAA8

Gene LinkOut

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