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ND-B14.5A NADH dehydrogenase (ubiquinone) B14.5 A subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31190, updated on 4-Jan-2025

Summary

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Official Symbol
ND-B14.5Aprovided by FlyBase
Official Full Name
NADH dehydrogenase (ubiquinone) B14.5 A subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0025839
Locus tag
Dmel_CG3621
See related
AllianceGenome:FB:FBgn0025839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
152A3.7; anon-2D; anon-2Db; BcDNA:RE75088; CG3621; Dmel\CG3621; dNDUFA7; dNDUFA7A; EG:152A3.7; N4AM; NDUFA7; RNAA
Summary
Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Part of respiratory chain complex I. Is expressed in adult head and adult heart. Orthologous to human NDUFA7 (NADH:ubiquinone oxidoreductase subunit A7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ND-B14.5A in Genome Data Viewer
Location:
2D6-2E1; 1-0.6 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2172526..2173432)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2066559..2067465)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4d1 Neighboring gene uncharacterized protein Neighboring gene mir-3641 stem loop Neighboring gene antisense RNA:CR45479 Neighboring gene Cytochrome P450 4d14 Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Zid BM, et al. Cell, 2009 Oct 2. PMID 19804760, Free PMC Article
  2. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
  3. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. Gandhi R, et al. DNA Cell Biol, 1992 Jun. PMID 1605861
  4. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
  5. Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. Yin S, et al. PLoS One, 2013. PMID 24069262, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IC
Inferred by Curator
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NADH dehydrogenase (ubiquinone) B14.5 A subunit
Names
CG3621-PA
CG3621-PB
FBpp0070370
NADH ubiquinone oxidoreductase B14.5A
NADH-ubiquinone oxidoreductase subunit B14.5a
NADH:ubiquinone oxidoreductase B14.5A subunit
ND-B14.5A-PA
ND-B14.5A-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2172526..2173432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297876.1 → NP_001284805.1  NADH dehydrogenase (ubiquinone) B14.5 A subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97418, Q8SYB3
    Conserved Domains (1) summary
    pfam07347
    Location:9 → 99
    CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)

  2. NM_130628.4 → NP_569984.2  NADH dehydrogenase (ubiquinone) B14.5 A subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569984.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O97418, Q8SYB3
    Related
    FBpp0070370
    Conserved Domains (1) summary
    pfam07347
    Location:9 → 99
    CI-B14_5a; NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O97418 O97418
Q8SYB3 Q8SYB3

Gene LinkOut

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