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pn prune [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31194, updated on 9-Dec-2024

Summary

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Official Symbol
pnprovided by FlyBase
Official Full Name
pruneprovided by FlyBase
Primary source
FLYBASE:FBgn0003116
Locus tag
Dmel_CG3461
See related
AllianceGenome:FB:FBgn0003116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3461; Dmel\CG3461; EG:152A3.5; N3; N4; TcD37
Summary
Enables cyclic-nucleotide phosphodiesterase activity. Involved in compound eye pigmentation; negative regulation of cAMP-mediated signaling; and pteridine metabolic process. Is active in mitochondrial matrix. Is expressed in organism. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
2E1-2E1; 1-0.8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2181211..2182916)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2075244..2076949)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1 Neighboring gene Nonsense-mediated mRNA 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Human Prune Regulates the Metabolism of Mammalian Inorganic Polyphosphate and Bioenergetics. Scoma ER, et al. Int J Mol Sci, 2023 Sep 8. PMID 37762163, Free PMC Article
  2. PAPER CHROMATOGRAPHY OF PTERIDINES OF PRUNE AND CLOT STOCKS OF DROSOPHILA MELANOGASTER. NARAYANAN Y, et al. Genetics, 1964 Sep. PMID 14207705, Free PMC Article
  3. [Transcription of the prune gene during a position effect of the mosaic type in Drosophila melanogaster]. Frolov MV, et al. Genetika, 1993 Sep. PMID 8276226
  4. [Region of the prune locus in Drosophila melanogaster is transcriptionally saturated]. Frolov MV, et al. Genetika, 1993 Sep. PMID 8276217
  5. The mRNA product of the Drosophila gene prune is spliced and encodes a protein containing a putative transmembrane domain. Frolov MV, et al. Mol Gen Genet, 1994 Feb. PMID 8121405

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
    Title: The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cyclic-nucleotide phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables exopolyphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in compound eye pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cAMP/PKA signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitochondrial DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pteridine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
prune
Names
CG3461-PA
pn-PA
se-like-62
transcription unit II
NP_476684.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2181211..2182916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057336.5 → NP_476684.1  prune [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O18399, Q629J6
    Related
    FBpp0070373
    Conserved Domains (2) summary
    COG1227
    Location:39 → 379
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:235 → 377
    DHHA2; DHHA2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18399 O18399
Q24465 Q24465
Q629J6 Q629J6

Gene LinkOut

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