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Nmd3 Nonsense-mediated mRNA 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31195, updated on 9-Dec-2024

Summary

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Official Symbol
Nmd3provided by FlyBase
Official Full Name
Nonsense-mediated mRNA 3provided by FlyBase
Primary source
FLYBASE:FBgn0023542
Locus tag
Dmel_CG3460
See related
AllianceGenome:FB:FBgn0023542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-2Eb; CG3460; Dmel\CG3460; dNmd3; EG:152A3.1; II; TcD12; TcD13
Summary
Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in ribosomal large subunit export from nucleus. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; gut section; and larval somatic muscle cell. Orthologous to human NMD3 (NMD3 ribosome export adaptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nmd3 in Genome Data Viewer
Location:
2E1-2E1; 1-0.8 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2182818..2184668, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2076851..2078701, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene Cytochrome P450 4ae1 Neighboring gene prune Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of the prune locus of Drosophila melanogaster. Teng DH, et al. Genetics, 1991 Jun. PMID 1649071, Free PMC Article
  2. A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein. Teng DH, et al. Nature, 1991 Oct 3. PMID 1654526
  3. Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis. Pulianmackal AJ, et al. Dis Model Mech, 2022 Mar 1. PMID 35107131, Free PMC Article
  4. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. Gandhi R, et al. DNA Cell Biol, 1992 Jun. PMID 1605861
  5. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ribosomal large subunit export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Nonsense-mediated mRNA 3
Names
CG3460-PA
Nmd3-PA
transcription unit III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2182818..2184668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057984.5 → NP_477332.1  Nonsense-mediated mRNA 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477332.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46050, Q9UB80
    Related
    FBpp0070409
    Conserved Domains (2) summary
    COG1499
    Location:21 → 390
    NMD3; NMD protein affecting ribosome stability and mRNA decay [Translation, ribosomal structure and biogenesis]
    pfam04981
    Location:27 → 255
    NMD3; NMD3 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46050 O46050
Q9UB80 Q9UB80

Gene LinkOut

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