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SmydA-8 SET and MYND domain containing, arthropod-specific, member 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31200, updated on 4-Jan-2025

Summary

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Official Symbol
SmydA-8provided by FlyBase
Official Full Name
SET and MYND domain containing, arthropod-specific, member 8provided by FlyBase
Primary source
FLYBASE:FBgn0053548
Locus tag
Dmel_CG33548
See related
AllianceGenome:FB:FBgn0053548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18033; CG32799; CG32800; CG33548; Dmel\CG33548; EG:103B4.4; EG:103B4.5; msta; Msta; MSTA
Summary
Predicted to enable S-adenosylmethionine-dependent methyltransferase activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in eye; photoreceptor neurons; and spermatozoon. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See SmydA-8 in Genome Data Viewer
Location:
2E2-2E2; 1-0.8 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2205515..2213809, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2099548..2107842, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Monocarboxylate transporter 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43637 Neighboring gene Fatty acyl-CoA reductase in oenocytes Neighboring gene Vinculin Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Germline transformation of Drosophila melanogaster with the piggyBac transposon vector. Handler AM, et al. Insect Mol Biol, 1999 Nov. PMID 10634970
  2. Alternative mechanisms for talin to mediate integrin function. Klapholz B, et al. Curr Biol, 2015 Mar 30. PMID 25754646, Free PMC Article
  3. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
  4. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
  5. CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells. Xu Y, et al. J Cell Sci, 2016 Jan 15. PMID 26598556, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-lysine N-methyltransferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SET and MYND domain containing, arthropod-specific, member 8
Names
CG33548-PA
CG33548-PB
CG33548-PC
CG33548-PD
SmydA-8-PA
SmydA-8-PB
SmydA-8-PC
SmydA-8-PD
msta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2205515..2213809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297883.1 → NP_001284812.1  SET and MYND domain containing, arthropod-specific, member 8, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46040, O46041, Q9UB82
    UniProtKB/TrEMBL
    B5RJI3, X2JDK3
    Conserved Domains (1) summary
    smart00317
    Location:189 → 293
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  2. NM_001014718.2 → NP_001014718.1  SET and MYND domain containing, arthropod-specific, member 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83501
    Conserved Domains (1) summary
    smart00317
    Location:199 → 279
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

  3. NM_001297882.1 → NP_001284811.1  SET and MYND domain containing, arthropod-specific, member 8, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284811.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JI38

  4. NM_001014717.2 → NP_001014717.1  SET and MYND domain containing, arthropod-specific, member 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014717.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46040, O46041, Q9UB82
    UniProtKB/TrEMBL
    B5RJI3, X2JDK3
    Conserved Domains (1) summary
    smart00317
    Location:189 → 293
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46040.3 O46040
P83501.2 P83501
X2JDK3 X2JDK3
X2JI38 X2JI38

Gene LinkOut

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