Dbf4 DBF4-CDC7 kinase regulatory subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dbf4provided by RGD
Official Full Name: DBF4-CDC7 kinase regulatory subunitprovided by RGD
Primary source: RGD:1305854
See related: EnsemblRapid:ENSRNOG00000050482 AllianceGenome:RGD:1305854
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305854
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Predicted to be located in nuclear body. Predicted to be part of Dbf4-dependent protein kinase complex. Orthologous to human DBF4 (DBF4-CDC7 kinase regulatory subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 109.7), Spleen (RPKM 77.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (26631491..26656080)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (25676570..25701152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (22898527..22914091)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of nuclear cell cycle DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Dbf4-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein DBF4 homolog A

Names: DBF4 homolog; DBF4 zinc finger; protein DBF4 homolog A-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191748.2 → NP_001178677.1 protein DBF4 homolog A

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A096MJF6

Related

ENSRNOP00000068111.2, ENSRNOT00000076123.4

Conserved Domains (2) summary

cd00027
Location:48 → 94

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

cl02684
Location:288 → 335

zf-DBF; DBF zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

26631491..26656080

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107501.2 → XP_038963429.1 protein DBF4 homolog A isoform X1

Conserved Domains (1) summary

cl02684
Location:287 → 334

zf-DBF; DBF zinc finger
XM_039107502.2 → XP_038963430.1 protein DBF4 homolog A isoform X2

UniProtKB/TrEMBL

A6K240

Conserved Domains (1) summary

cl02684
Location:50 → 97

zf-DBF; DBF zinc finger
XM_039107503.2 → XP_038963431.1 protein DBF4 homolog A isoform X2

UniProtKB/TrEMBL

A6K240

Conserved Domains (1) summary

cl02684
Location:50 → 97

zf-DBF; DBF zinc finger