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kz kurz [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31205, updated on 9-Dec-2024

Summary

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Official Symbol
kzprovided by FlyBase
Official Full Name
kurzprovided by FlyBase
Primary source
FLYBASE:FBgn0001330
Locus tag
Dmel_CG3228
See related
AllianceGenome:FB:FBgn0001330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3228; Dmel\CG3228; EG:30B8.2; l(1)2Eb; l(1)N4; l67; N1; N8
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be active in nucleolus. Is expressed in ovary. Human ortholog(s) of this gene implicated in 46,XY sex reversal. Orthologous to human DHX37 (DEAH-box helicase 37). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
2F1-2F1; 1-0.9 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2237858..2242035, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2131891..2136068, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vinculin Neighboring gene uncharacterized protein Neighboring gene pecanex Neighboring gene female sterile (1) K10 Neighboring gene Odorant receptor 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The kurz locus of Drosophila melanogaster shares conserved motifs with a family of yeast ATP dependent splicing factors. Tirronen M, et al. Nucleic Acids Res, 1992 Apr 11. PMID 1579473, Free PMC Article
  2. Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein. LaBonne SG, et al. Dev Biol, 1989 Nov. PMID 2478400
  3. Oocyte-specific transcription of fs(1)K10: a Drosophila gene affecting dorsal-ventral developmental polarity. Haenlin M, et al. EMBO J, 1987 Mar. PMID 16453754, Free PMC Article
  4. A 43 kilobase cosmid P transposon rescues the fs(1)K10 morphogenetic locus and three adjacent Drosophila developmental mutants. Haenlin M, et al. Cell, 1985 Apr. PMID 2985265
  5. Position-effect variegation in Drosophila melanogaster X chromosome inversion with a breakpoint in a satellite block and its suppression in a secondary rearrangement. Tolchkov EV, et al. Chromosoma, 1997 Dec. PMID 9426284

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kurz
Names
CG3228-PA
CG3228-PB
kz-PA
kz-PB
NP_001284815.1
NP_476591.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    2237858..2242035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057243.4 → NP_476591.1  kurz, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46072
    UniProtKB/TrEMBL
    Q6NR37, X2JCE0
    Related
    FBpp0070403
    Conserved Domains (6) summary
    smart00490
    Location:619 → 704
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:774 → 859
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:237 → 1058
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:279 → 418
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:915 → 1039
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    cl21455
    Location:369 → 500
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001297886.1 → NP_001284815.1  kurz, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284815.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46072
    UniProtKB/TrEMBL
    Q6NR37, X2JCE0
    Conserved Domains (6) summary
    smart00490
    Location:619 → 704
    HELICc; helicase superfamily c-terminal domain
    smart00847
    Location:774 → 859
    HA2; Helicase associated domain (HA2) Add an annotation
    COG1643
    Location:237 → 1058
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd00046
    Location:279 → 418
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam07717
    Location:915 → 1039
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    cl21455
    Location:369 → 500
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46072.1 O46072
Q6NR37 Q6NR37
Q9NFN0 Q9NFN0
X2JCE0 X2JCE0

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