tko technical knockout [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tkoprovided by FlyBase
Official Full Name: technical knockoutprovided by FlyBase
Primary source: FLYBASE:FBgn0003714
Locus tag: Dmel_CG7925
See related: AllianceGenome:FB:FBgn0003714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7925; Dmel\CG7925; EG:BACH59J11.1; l(1)3Ab; l(1)tko; MRP-S12; mRpS12; MRPS12; mt-rps12; rps12; S12; Tko
Summary: Predicted to be a structural constituent of ribosome. Involved in several processes, including male courtship behavior; mechanosensory behavior; and sensory perception of sound. Predicted to be part of mitochondrial small ribosomal subunit. Predicted to be active in ribosome. Is expressed in several structures, including adult head; anal pad primordium; embryonic/larval midgut primordium; gut section; and visceral mesoderm derivative. Used to study epilepsy; mitochondrial metabolism disease; and sensorineural hearing loss. Orthologous to human MRPS12 (mitochondrial ribosomal protein S12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2442313..2443976, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2336346..2338009, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IEA Inferred from Electronic Annotation more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables structural constituent of ribosome	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in courtship behavior	TAS Traceable Author Statement more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mechanosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	TAS Traceable Author Statement more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mitochondrial small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial small ribosomal subunit	TAS Traceable Author Statement more info	PubMed
is_active_in ribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in ribosome	IEA Inferred from Electronic Annotation more info
part_of small ribosomal subunit	IEA Inferred from Electronic Annotation more info

Names: CG7925-PB; CG7925-PC; mitochondrial ribosomal protein S12; mitoribosomal protein S12; tko-PB; tko-PC

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